Skip Navigation


Cerebral Cortex Advance Access originally published online on March 2, 2005
Cerebral Cortex 2005 15(12):1835-1847; doi:10.1093/cercor/bhi061
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
15/12/1835    most recent
bhi061v2
bhi061v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (21)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Schulz, G.M.
Right arrow Articles by Braun, A.R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schulz, G.M.
Right arrow Articles by Braun, A.R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2005.

Functional Neuroanatomy of Human Vocalization: An H215O PET Study

G.M. Schulz1, M. Varga2, K. Jeffires2, C.L. Ludlow3 and A.R. Braun2

1 Department of Speech and Hearing Science, The George Washington University, USA, 2 Language Section, Voice, Speech and Language Branch, NIDCD, NIH, Bethesda, MD 2089, USA and 3 Laryngeal and Speech Section, Medical Neurology Branch, NINDS, NIH, Bethesda, MD 2089, USA

Address correspondence to G. M. Schulz, The George Washington University, Department of Speech and Hearing Science, 1922 F. St., N.W. Room 406-D, Washington, DC, 20052, USA. Email: schulz{at}egwu.edu.

Vocalization in lower animals is associated with a well-described visceromotor call system centered on the mesencephalic periacqueductal grey matter (PAG), which is itself regulated by paramedian cortical structures. To determine the role this phylogenetically older system plays in human phonation, we contrasted voiced and unvoiced speech using positron emission tomography and then evaluated functional connectivity of regions that significantly differentiated these conditions. Vocalization was associated with increased and highly correlated activity within the midline structures — PAG and paramedian cortices — described in lower mammalian species. Concurrent activation and connectivity of neocortical and subcortical motor regions — medial and lateral premotor structures and elements of basal ganglia thalamocortical circuitry — suggest a mechanism by which this system may have come under an increasing degree of voluntary control in humans. Additionally, areas in the temporal lobe and cerebellum were selectively activated during voiced but not unvoiced speech. These regions are functionally coupled to both visceromotor and neocortical motor areas during production of voiced speech, suggesting they may play a central role in self-monitoring and feedback regulation of human phonation.

Key Words: PAG • self-monitoring • species-specific calls • speech production • voice


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
C. A. Kell, K. Neumann, K. von Kriegstein, C. Posenenske, A. W. von Gudenberg, H. Euler, and A.-L. Giraud
How the brain repairs stuttering
Brain, October 1, 2009; 132(10): 2747 - 2760.
[Abstract] [Full Text] [PDF]

Home page
 Speech Science and Orofacial DisordersHome page
M. E. Estep and S. M. Barlow
The Connectivity of Orofacial Systems
Speech Science and Orofacial Disorders, July 1, 2009; 19(1): 28 - 36.
[Abstract] [Full Text] [PDF]

Home page
 AJSLPHome page
S. Narayana, A. Jacks, D. A. Robin, H. Poizner, W. Zhang, C. Franklin, M. Liotti, D. Vogel, and P. T. Fox
A Noninvasive Imaging Approach to Understanding Speech Changes Following Deep Brain Stimulation in Parkinson's Disease
Am J Speech Lang Pathol, May 1, 2009; 18(2): 146 - 161.
[Abstract] [Full Text] [PDF]

Home page
 JSLHRHome page
M. van Mersbergen, C. Patrick, and L. Glaze
Functional Dysphonia During Mental Imagery: Testing the Trait Theory of Voice Disorders
J Speech Lang Hear Res, December 1, 2008; 51(6): 1405 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 JSLHRHome page
C. L. Ludlow, J. Hoit, R. Kent, L. O. Ramig, R. Shrivastav, E. Strand, K. Yorkston, and C. M. Sapienza
Translating Principles of Neural Plasticity Into Research on Speech Motor Control Recovery and Rehabilitation
J Speech Lang Hear Res, February 1, 2008; 51(1): S240 - S258.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
V. M. Henriquez, G. M. Schulz, S. Bielamowicz, and C. L. Ludlow
Laryngeal reflex responses are not modulated during human voice and respiratory tasks
J. Physiol., December 15, 2007; 585(3): 779 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Nakamura, S. Dehaene, A. Jobert, D. Le Bihan, and S. Kouider
Task-specific change of unconscious neural priming in the cerebral language network
PNAS, December 4, 2007; 104(49): 19643 - 19648.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
P. P. Urban, R. Rolke, S. Wicht, A. Keilmann, P. Stoeter, H. C. Hopf, and M. Dieterich
Left-hemispheric dominance for articulation: a prospective study on acute ischaemic dysarthria at different localizations
Brain, March 1, 2006; 129(3): 767 - 777.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.