Cerebral Cortex Advance Access originally published online on February 16, 2005
Cerebral Cortex 2005 15(11):1815-1821; doi:10.1093/cercor/bhi058
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Physiological Dissociation in Hippocampal Subregions in Response to Amygdala Stimulation
Department of Psychology and the Brain and Behavior Research Center, University of Haifa, Israel
Address correspondence to Rose-Marie Vouimba, Brain and Behavior Research Center, Department of Psychology, University of Haifa, Haifa 31905, Israel. Email: rvouimba{at}psy.haifa.ac.il.
Previous studies indicated that the amygdala, when activated by emotional or electrical stimulation, modulates hippocampal-dependent memory processes and synaptic plasticity. Although the modulatory effect of the amygdala has often been generalized to the hippocampal formation, studies suggest that hippocampal subregions may display distinct functional profiles and may respond distinctively to amygdala activation. In this study we assessed the effect of basolateral amygdala (BLA) stimulation on long-term potentiation (LTP) — a synaptic model of memory — induced by a standard (sdTS) or a strong theta stimulation (sgTS) in the hippocampal dentate gyrus (DG) and CA1, in anesthetized rats. The modulatory stimulation was applied 30 s before or after the tetanus stimulation. Results show that while BLA activation impaired CA1 LTP induced with an sdTS, it enhanced LTP in the DG under both sdTS and sgTS conditions. These findings provide evidence for a differential amygdalar control of hippocampal memory subsystems, and may contribute to the understanding of the complexity of memory processes under stressful conditions.
Key Words: amygdala • hippocampus • memory • plasticity • stress
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