Skip Navigation


Cerebral Cortex Advance Access originally published online on February 9, 2005
Cerebral Cortex 2005 15(10):1632-1636; doi:10.1093/cercor/bhi041
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
15/10/1632    most recent
bhi041v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Schmid, R. S.
Right arrow Articles by Anton, E. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schmid, R. S.
Right arrow Articles by Anton, E. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Reelin, Integrin and Dab1 Interactions during Embryonic Cerebral Cortical Development

Ralf S. Schmid1, Rebecca Jo1, Stephanie Shelton1, Jordan A. Kreidberg2 and E. S. Anton1

1 UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA and 2 Department of Medicine, Children's Hospital, Boston and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA

Address correspondence to E.S. Anton, UNC Neuroscience Center and the Department of Cell and Molecular Physiology, Rm 7109B, 103 Mason Farm Rd, The University of North Carolina School of Medicine, Chapel Hill, NC 27599-7250, USA. Email: anton{at}med.unc.edu.

Extracellular matrix-like molecule reelin and cell surface adhesion receptors such as {alpha}3ß1 integrin can regulate neuronal migration and position in the developing cerebral cortex. Here we show that {alpha}3ß1 integrin binds to the N-terminal region of reelin, a site distinct from the region of reelin shown to associate with other reelin receptors such as VLDLR/ApoER2. Furthermore, Dab1, a member of the reelin signaling pathway, can complex with the cytoplasmic region of ß1 integrin in a reelin-dependent manner. Thus, {alpha}3ß1 integrin–reelin interactions may contribute to appropriate neuronal placement in the developing cerebral cortex.

Key Words: cerebral cortex • Dab1 • integrin • neuronal migration • reelin


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
F. Causeret, M. Terao, T. Jacobs, Y. V. Nishimura, Y. Yanagawa, K. Obata, M. Hoshino, and M. Nikolic
The p21-Activated Kinase Is Required for Neuronal Migration in the Cerebral Cortex
Cereb Cortex, August 12, 2008; (2008) bhn133v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Groc, D. Choquet, F. A. Stephenson, D. Verrier, O. J. Manzoni, and P. Chavis
NMDA Receptor Surface Trafficking and Synaptic Subunit Composition Are Developmentally Regulated by the Extracellular Matrix Protein Reelin
J. Neurosci., September 19, 2007; 27(38): 10165 - 10175.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.