Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Patz, S.
Right arrow Articles by Wahle, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Patz, S.
Right arrow Articles by Wahle, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex March 2004; 14:342-351
© Oxford University Press 2004

Parvalbumin Expression in Visual Cortical Interneurons Depends on Neuronal Activity and TrkB Ligands during an Early Period of Postnatal Development

Silke Patz, Jochen Grabert, Thorsten Gorba, Marcus J. Wirth and Petra Wahle

AG Entwicklungsneurobiologie, Fakultät für Biologie, Ruhr-Universität, ND 6/72, D-44780 Bochum, Germany

The differentiation of cortical interneurons is controlled by environmental factors. Here, we describe the role of activity and neurotrophins in regulating parvalbumin (PARV) expression using organotypic cultures (OTC) of rat visual cortex as model system. In OTC, PARV expression was dramatically delayed. The organotypic proportion of ~6% PARV neurons was not established before 50–70 DIV, whereas in vivo all neurons are present until P20. Thalamic afferents increased cortical PARV mRNA in OTC, but not to the age-matched in vivo level. During the first 10 DIV, BDNF and NT-4 accelerated PARV mRNA expression in a Trk receptor and MEK2 dependent manner. The BDNF action required PI3 kinase signalling. PARV expression required activity. The proportion of neurons which managed to up-regulate PARV was inversely related to the duration of early transient periods of activity deprivation. Long-term activity-deprived OTC completely failed to up-regulate PARV mRNA. Both TrkB ligands failed to promote PARV expression in activity-deprived OTC. However, a few basket and chandelier neurons were observed, suggesting that the development of class-specific morphological features is activity-independent. Once established, PARV expression became resistant to late-onset activity deprivation. In conclusion, PARV expression depended on activity and TrkB ligands which appear to prime the PARV expression already before its developmental onset.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
H. M. Morris, T. Hashimoto, and D. A. Lewis
Alterations in Somatostatin mRNA Expression in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia or Schizoaffective Disorder
Cereb Cortex, July 1, 2008; 18(7): 1575 - 1587.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. M. Friel, T. Drew, and J. H. Martin
Differential Activity-Dependent Development of Corticospinal Control of Movement and Final Limb Position During Visually Guided Locomotion
J Neurophysiol, May 1, 2007; 97(5): 3396 - 3406.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Itami, F. Kimura, and S. Nakamura
Brain-Derived Neurotrophic Factor Regulates the Maturation of Layer 4 Fast-Spiking Cells after the Second Postnatal Week in the Developing Barrel Cortex
J. Neurosci., February 28, 2007; 27(9): 2241 - 2252.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
N. H. Woo and B. Lu
Regulation of cortical interneurons by neurotrophins: from development to cognitive disorders.
Neuroscientist, February 1, 2006; 12(1): 43 - 56.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.