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Cerebral Cortex February 2004; 14:224-229
© Oxford University Press 2004

Acute Stress-induced Changes in Hippocampal/Prefrontal Circuits in Rats: Effects of Antidepressants

Cyril Rocher1,3, Michael Spedding2, Carmen Munoz2 and Thérèse M. Jay1,3

1 NAMC, CNRS UMR 8620, Bat. 446, Université Paris-Sud, 91405 Orsay, France, 2 I.R.I.SERVIER, 31 rue du Pont, 92578, Neuilly sur Seine Cedex, France

3 Present address: E0117 INSERM—Paris 5, Hôpital Sainte-Anne, 2ter rue d’Alésia, 75014 Paris, France

Acute stress inhibits long-term potentiation (LTP) at synapses from the hippocampus to prefrontal cortex in the rat, a model of the dysfunction in the anterior cingulate/orbitofrontal cortices which has been observed in human depression. We demonstrate that the antidepressants tianeptine and, to a lesser extent, fluoxetine, are able to reverse the impairment in LTP, a measure of frontal synaptic plasticity, caused by stress on an elevated platform. LTP was induced by stimulation of hippocampal outflow. Beneficial effects on neuronal plasticity, defined as a reversal of the effects of stress in this paradigm, can be considered as a new animal model for the impact of stress on hippocampal/frontal circuits, a key target in psychiatric diseases.


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