Cerebral Cortex, Vol. 13, No. 4, 422-433,
April 2003
© 2003 Oxford University Press
Very Slow Activity Fluctuations in Monkey Visual Cortex: Implications for Functional Brain Imaging
Max Planck Institut für biologische Kybernetik, Spemannstraße 38, 72076 Tübingen, Germany
Address correspondence to David A. Leopold, Max Planck Institut für biologische Kybernetik, Spemannstraße 38, 72076 Tübingen, Germany. Email: david.leopold{at}tuebingen.mpg.de.
We examined fluctuations in band-limited power (BLP) of local field potential (LFP) signals recorded from multiple electrodes in visual cortex of the monkey during different behavioral states. We asked whether such signals demonstrated coherent fluctuations over time-scales of seconds and minutes, and would thus serve as good candidates for direct comparison with data obtained from functional magnetic resonance imaging (fMRI). We obtained the following results. (i) The BLP of the local field displayed fluctuations at many time-scales, with particularly large amplitude at very low frequencies (<0.1 Hz). (ii) These fluctuations exhibited high coherence between electrode pairs, particularly for BLP signals derived from the gamma (g) frequency range. (iii) Coherence in the BLP, unlike that in the raw LFP, did not fall off sharply as a function of cortical distance. (iv) The structure and coherence of BLP changes were highly similar under distinctly different behavioral states. These results demonstrate the existence of widespread coherent activity fluctuations in the brain of the awake monkey over very long time-scales. We propose that such signals may make a significant contribution to the high variability observed in the time course of physiological signals, including those measured with functional imaging techniques. The results are discussed in the context of combined fMRI/electrophysiological recordings.
![]()
CiteULike
Connotea
Del.icio.us What's this?
This article has been cited by other articles:
![]() |
S. M. Montgomery, A. Sirota, and G. Buzsaki Theta and Gamma Coordination of Hippocampal Networks during Waking and Rapid Eye Movement Sleep J. Neurosci., June 25, 2008; 28(26): 6731 - 6741. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Eichele, S. Debener, V. D. Calhoun, K. Specht, A. K. Engel, K. Hugdahl, D. Y. von Cramon, and M. Ullsperger Prediction of human errors by maladaptive changes in event-related brain networks PNAS, April 22, 2008; 105(16): 6173 - 6178. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Linkenkaer-Hansen, D. J. A. Smit, A. Barkil, T. E. M. van Beijsterveldt, A. B. Brussaard, D. I. Boomsma, A. van Ooyen, and E. J. C. de Geus Genetic Contributions to Long-Range Temporal Correlations in Ongoing Oscillations J. Neurosci., December 12, 2007; 27(50): 13882 - 13889. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Lu, Y. Zuo, H. Gu, J. A. Waltz, W. Zhan, C. A. Scholl, W. Rea, Y. Yang, and E. A. Stein Synchronized delta oscillations correlate with the resting-state functional MRI signal PNAS, November 13, 2007; 104(46): 18265 - 18269. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. Fair, N. U. F. Dosenbach, J. A. Church, A. L. Cohen, S. Brahmbhatt, F. M. Miezin, D. M. Barch, M. E. Raichle, S. E. Petersen, and B. L. Schlaggar Development of distinct control networks through segregation and integration PNAS, August 14, 2007; 104(33): 13507 - 13512. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Mantini, M. G. Perrucci, C. Del Gratta, G. L. Romani, and M. Corbetta Electrophysiological signatures of resting state networks in the human brain PNAS, August 7, 2007; 104(32): 13170 - 13175. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. H. Donner, M. Siegel, R. Oostenveld, P. Fries, M. Bauer, and A. K. Engel Population Activity in the Human Dorsal Pathway Predicts the Accuracy of Visual Motion Detection J Neurophysiol, July 1, 2007; 98(1): 345 - 359. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Monto, S. Vanhatalo, M. D. Holmes, and J. M. Palva Epileptogenic Neocortical Networks Are Revealed by Abnormal Temporal Dynamics in Seizure-Free Subdural EEG Cereb Cortex, June 1, 2007; 17(6): 1386 - 1393. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. H. Chen-Bee, T. Agoncillo, Y. Xiong, and R. D. Frostig The Triphasic Intrinsic Signal: Implications for Functional Imaging J. Neurosci., April 25, 2007; 27(17): 4572 - 4586. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Siegel, T. H. Donner, R. Oostenveld, P. Fries, and A. K. Engel High-Frequency Activity in Human Visual Cortex Is Modulated by Visual Motion Strength Cereb Cortex, March 1, 2007; 17(3): 732 - 741. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Vincent, A. Z. Snyder, M. D. Fox, B. J. Shannon, J. R. Andrews, M. E. Raichle, and R. L. Buckner Coherent Spontaneous Activity Identifies a Hippocampal-Parietal Memory Network J Neurophysiol, December 1, 2006; 96(6): 3517 - 3531. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. J. Drew and L. F. Abbott Models and Properties of Power-Law Adaptation in Neural Systems J Neurophysiol, August 1, 2006; 96(2): 826 - 833. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. J. Drew and L. F. Abbott Extending the effects of spike-timing-dependent plasticity to behavioral timescales PNAS, June 6, 2006; 103(23): 8876 - 8881. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Achard, R. Salvador, B. Whitcher, J. Suckling, and E. Bullmore A Resilient, Low-Frequency, Small-World Human Brain Functional Network with Highly Connected Association Cortical Hubs J. Neurosci., January 4, 2006; 26(1): 63 - 72. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Linkenkaer-Hansen, S. Monto, H. Rytsala, K. Suominen, E. Isometsa, and S. Kahkonen Breakdown of Long-Range Temporal Correlations in Theta Oscillations in Patients with Major Depressive Disorder J. Neurosci., November 2, 2005; 25(44): 10131 - 10137. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-D. Haynes, J. Tregellas, and G. Rees Attentional integration between anatomically distinct stimulus representations in early visual cortex PNAS, October 11, 2005; 102(41): 14925 - 14930. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Kohn and M. A. Smith Stimulus Dependence of Neuronal Correlation in Primary Visual Cortex of the Macaque J. Neurosci., April 6, 2005; 25(14): 3661 - 3673. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Vanhatalo, J. M. Palva, M. D. Holmes, J. W. Miller, J. Voipio, and K. Kaila Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep PNAS, April 6, 2004; 101(14): 5053 - 5057. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Laufs, K. Krakow, P. Sterzer, E. Eger, A. Beyerle, A. Salek-Haddadi, and A. Kleinschmidt Electroencephalographic signatures of attentional and cognitive default modes in spontaneous brain activity fluctuations at rest PNAS, September 16, 2003; 100(19): 11053 - 11058. [Abstract] [Full Text] [PDF] |
||||



