Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (45)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Mottaghy, F.M.
Right arrow Articles by Pascual-Leone, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mottaghy, F.M.
Right arrow Articles by Pascual-Leone, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol. 12, No. 4, 369-375, April 2002
© 2002 Oxford University Press

Segregation of Areas Related to Visual Working Memory in the Prefrontal Cortex Revealed by rTMS

F.M. Mottaghy1,2, M. Gangitano1, R. Sparing1, B.J. Krause2 and A. Pascual-Leone1

1 Laboratory for Magnetic Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, 330 Brookline Avenue, Kirstein Building KS 454, Boston, MA 02215, USA and , 2 Department of Nuclear Medicine (KME), Research Center Jülich, D-52426 Jülich, Germany

Alvaro Pascual-Leone, Laboratory for Magnetic Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Kirstein Hall KS452, Boston, MA 02115, USA. Email: apleone{at}caregroup.harvard.edu.

The functional organization of working memory (WM) in the human prefrontal cortex remains unclear. Storage and processing functions might be segregated in ventral and dorsal areas of the prefrontal cortex, respectively. If so, storage functions might be spared, irrespective of informational domain, following damage or dysfunction in dorsolateral areas. Alternatively, WM and prefrontal function in general might be segregated according to informational domains (e.g. spatial versus object-based information). In the present study we used repetitive transcranial magnetic stimulation (rTMS) to directly test these competing hypotheses. We applied rTMS to transiently and selectively disrupt the function of the dorsomedial, dorsolateral or ventral prefrontal cortex in normal human volunteers performing either a spatial or a face-recognition delayed-response task. Performance in the spatial task was impaired by rTMS of the dorsomedial prefrontal cortex. Performance in the face-recognition (non-spatial) task was impaired by rTMS of the ventral prefrontal cortex. Transient disruption of the dorsolateral prefrontal cortex affected performance in both tasks. These findings provide evidence of domain-specific segregation of WM functions in widely separated areas of prefrontal cortex.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
B. Luber, A. D. Stanford, P. Bulow, T. Nguyen, B. C. Rakitin, C. Habeck, R. Basner, Y. Stern, and S. H. Lisanby
Remediation of Sleep-Deprivation-Induced Working Memory Impairment with fMRI-Guided Transcranial Magnetic Stimulation
Cereb Cortex, September 1, 2008; 18(9): 2077 - 2085.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
H. Burianova and C. L. Grady
Common and unique neural activations in autobiographical, episodic, and semantic retrieval.
J. Cogn. Neurosci., September 1, 2007; 19(9): 1520 - 1534.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
J. A. Johnson, A. P. Strafella, and R. J. Zatorre
The role of the dorsolateral prefrontal cortex in bimodal divided attention: two transcranial magnetic stimulation studies.
J. Cogn. Neurosci., June 1, 2007; 19(6): 907 - 920.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
D. E.J. Linden
The Working Memory Networks of the Human Brain
Neuroscientist, June 1, 2007; 13(3): 257 - 267.
[Abstract] [PDF]

Home page
 J. Cogn. Neurosci.Home page
E. Rounis, K. Yarrow, and J. C. Rothwell
Effects of rTMS Conditioning over the Fronto-parietal Network on Motor versus Visual Attention.
J. Cogn. Neurosci., March 1, 2007; 19(3): 513 - 524.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Rounis, K. E. Stephan, L. Lee, H. R. Siebner, A. Pesenti, K. J. Friston, J. C. Rothwell, and R. S. J. Frackowiak
Acute changes in frontoparietal activity after repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex in a cued reaction time task.
J. Neurosci., September 20, 2006; 26(38): 9629 - 9638.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Ueki, T. Mima, K. Nakamura, T. Oga, H. Shibasaki, T. Nagamine, and H. Fukuyama
Transient Functional Suppression and Facilitation of Japanese Ideogram Writing Induced by Repetitive Transcranial Magnetic Stimulation of Posterior Inferior Temporal Cortex.
J. Neurosci., August 15, 2006; 26(33): 8523 - 8530.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Sayala, J. B. Sala, and S. M. Courtney
Increased Neural Efficiency with Repeated Performance of a Working Memory Task is Information-type Dependent
Cereb Cortex, May 1, 2006; 16(5): 609 - 617.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
G. Thut, A. Nietzel, and A. Pascual-Leone
Dorsal Posterior Parietal rTMS Affects Voluntary Orienting of Visuospatial Attention
Cereb Cortex, May 1, 2005; 15(5): 628 - 638.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
E. M. Robertson, H. Theoret, and A. Pascual-Leone
Studies in Cognition: The Problems Solved and Created by Transcranial Magnetic Stimulation
J. Cogn. Neurosci., October 1, 2003; 15(7): 948 - 960.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
F. M. Mottaghy, M. Gangitano, C. Horkan, Y. Chen, A. Pascual-Leone, and G. Schlaug
Repetitive TMS temporarily alters brain diffusion
Neurology, May 13, 2003; 60(9): 1539 - 1541.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.