Cerebral Cortex, Vol. 12, No. 3, 223-224,
March 2002
© 2002 Oxford University Press
CC COMMENTARY
Intrinsic Signals and Functional Brain Mapping: Caution, Blood Vessels at Work
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
Costantino Iadecola, Department of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, USA.Email: iadec001@tc.umn.edu.
It has long been thought that there is a close relationship between brain activity and cerebral blood flow [reviewed by Raichle (Raichle, 1998
)]. While in 1890 Roy and Sherrington proposed the concept of an ‘intrinsic mechanisms’ responsible for coupling neural activity to blood flow (Roy and Sherrington, 1890), more than a decade earlier the Italian physiologist Angelo Mosso was already undertaking a detailed study of the changes in cerebral hemodynamics associated with various psychological states in humans (Mosso, 1881). Following up on these pioneering efforts, our understanding of the localization of brain function has advanced considerably thanks to techniques that detect the changes in brain blood flow associated with brain activity (Table 1). One of the
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