Cerebral Cortex, Vol. 11, No. 6, 485-489,
June 2001
© 2001 Oxford University Press
Olfactory Learning Modifies Predisposition for Long-term Potentiation and Long-term Depression Induction in the Rat Piriform (Olfactory) Cortex
1 Departments of Morphology and , 2 Physiology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
Learning-related modifications in predisposition for long-term potentiation (LTP) and long-term depression (LTD) were studied in brain slices of the rat piriform cortex following olfactory learning. Rats were trained to discriminate between pairs of odors until they demonstrated rule learning. We have previously shown that such training is accompanied by enhanced neuronal excitability and increased synaptic transmission in the intrinsic synaptic pathway. Here we show that the susceptibility for further enhancing synaptic connectivity by inducing LTP in slices from trained rats is markedly reduced after training, compared with slices from pseudo-trained and naive rats. Accordingly, while 900 stimuli at 1 Hz did not induce LTD in slices from control rats, it induced significant LTD in slices from trained rats. Post-tetanic potentiation (PTP) was also reduced after training, indicating that synaptic release is enhanced after odor learning, as previously suggested. We suggest that learning-related cellular modifications and activity-dependent synaptic plasticity share a common mechanism in the primary olfactory cortex. Our data also support the prediction generated according to the sliding modification threshold theory that learning should be accompanied by reduced capability of inducing LTP and increased susceptibility for LTD induction.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Brosh and E. Barkai Learning-induced enhancement of feedback inhibitory synaptic transmission Learn. Mem., June 19, 2009; 16(7): 413 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Cohen, I. Reuveni, E. Barkai, and M. Maroun Olfactory Learning-Induced Long-Lasting Enhancement of Descending and Ascending Synaptic Transmission to the Piriform Cortex J. Neurosci., June 25, 2008; 28(26): 6664 - 6669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Brigman, M. Feyder, L. M. Saksida, T. J. Bussey, M. Mishina, and A. Holmes Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit Learn. Mem., January 28, 2008; 15(2): 50 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Jones, L. Stanek-Rattiner, M. Davis, and K. J. Ressler Differential regional expression of brain-derived neurotrophic factor following olfactory fear learning Learn. Mem., December 17, 2007; 14(12): 816 - 820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Young and Q.-Q. Sun Long-Term Modifications in the Strength of Excitatory Associative Inputs in the Piriform Cortex Chem Senses, October 1, 2007; 32(8): 783 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kopp, F. Longordo, J. R. Nicholson, and A. Luthi Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function J. Neurosci., November 29, 2006; 26(48): 12456 - 12465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lebel, N. Sidhu, E. Barkai, and E. M. Quinlan Learning in the absence of experience-dependent regulation of NMDAR composition Learn. Mem., September 1, 2006; 13(5): 566 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Zelcer, H. Cohen, G. Richter-Levin, T. Lebiosn, T. Grossberger, and E. Barkai A Cellular Correlate of Learning-induced Metaplasticity in the Hippocampus Cereb Cortex, April 1, 2006; 16(4): 460 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kemp and D. Manahan-Vaughan The 5-Hydroxytryptamine4 Receptor Exhibits Frequency-dependent Properties in Synaptic Plasticity and Behavioural Metaplasticity in the Hippocampal CA1 Region In vivo Cereb Cortex, July 1, 2005; 15(7): 1037 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Froc and R. J. Racine Interactions Between LTP- and LTD-Inducing Stimulation in the Sensorimotor Cortex of the Awake Freely Moving Rat J Neurophysiol, January 1, 2005; 93(1): 548 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.M. McNamara, T.A. Cleland, and C. Linster Characterization of the Synaptic Properties of Olfactory Bulb Projections Chem Senses, March 1, 2004; 29(3): 225 - 233. [Abstract] [Full Text] [PDF]
|
|