Cerebral Cortex, Vol. 11, No. 4, 360-373,
April 2001
© 2001 Oxford University Press
Relationship between EEG Potentials and Intracellular Activity of Striatal and Cortico-striatal Neurons: an In Vivo Study under Different Anesthetics
Institut des Neurosciences, Département de Neurochimie-Anatomie, CNRS UMR 7624, Université Pierre et Marie Curie, 9 quai Saint-Bernard, F-75005 Paris, France
The functions of the basal ganglia are achieved through excitation of striatal output neurons (SONs) by converging cortical glutamergic afferents. We assessed the relationship between different patterns of activity in cortico-striatal (C-S) cells and the electrical behavior of SONs in vivo. Intracellular activities of rat C-S neurons in the orofacial motor cortex and of SONs, located in the projection field of this cortical region, were recorded under different anesthetics, which generate various temporal patterns of cortical activity. A surface electroencephalogram (EEG) of the orofacial motor cortex was simultaneously performed with intracellular recordings and EEG waves were used as correlates of a coherent synaptic activity in cortical neurons. Under barbiturate anesthesia C-S neurons showed rhythmic (5–7 Hz) supra-threshold depolarizations in phase with large amplitude EEG waves. The correlative activity of SONs was characterized by large amplitude oscillation-like synaptic depolarizations that could trigger action potentials. Under ketamine–xylazine anesthesia C-S neurons exhibited a step-like behavior consisting of depolarizing plateaus (up states), leading to multiple spike discharges, interrupted by hyperpolarizing periods (down states). The related activity of SONs was step-like membrane potential fluctuations with firing confined to the early part of the striatal up state. In C-S neurons and SONs up states coincided with slow recurrent EEG waves (~1 Hz). Finally, under neurolept-analgesia an apparently disorganized EEG activity was associated with a lack of rhythmic discharge in C-S neurons. This uncorrelated activity in C-S neurons resulted in an absence of spontaneous firing as well as of large amplitude synaptic depolarizations in SONs. In the present study we demonstrate that SONs shape their input–output relationship by filtering out uncorrelated synaptic activity and that a minimal synchronization in the cortico-striatal afferents is required to produce significant synaptic depolarization in SONs.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. T. Paz, Sév. Mahon, P. Tiret, S.ép. Genet, B. Delord, and S.ép. Charpier Multiple forms of activity-dependent intrinsic plasticity in layer V cortical neurones in vivo J. Physiol., July 1, 2009; 587(13): 3189 - 3205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Dehorter, C. Guigoni, C. Lopez, J. Hirsch, A. Eusebio, Y. Ben-Ari, and C. Hammond Dopamine-Deprived Striatal GABAergic Interneurons Burst and Generate Repetitive Gigantic IPSCs in Medium Spiny Neurons J. Neurosci., June 17, 2009; 29(24): 7776 - 7787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Dejean, B. Hyland, and G. Arbuthnott Cortical Effects of Subthalamic Stimulation Correlate with Behavioral Recovery from Dopamine Antagonist Induced Akinesia Cereb Cortex, May 1, 2009; 19(5): 1055 - 1063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sharott, C. K. E. Moll, G. Engler, M. Denker, S. Grun, and A. K. Engel Different Subtypes of Striatal Neurons Are Selectively Modulated by Cortical Oscillations J. Neurosci., April 8, 2009; 29(14): 4571 - 4585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Galinanes, I. R. E. Taravini, and M. Gustavo Murer Dopamine-Dependent Periadolescent Maturation of Corticostriatal Functional Connectivity in Mouse J. Neurosci., February 25, 2009; 29(8): 2496 - 2509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Pomata, M. A. Belluscio, L. A. Riquelme, and M. G. Murer NMDA Receptor Gating of Information Flow through the Striatum In Vivo J. Neurosci., December 10, 2008; 28(50): 13384 - 13389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Dejean, C. E. Gross, B. Bioulac, and T. Boraud Dynamic Changes in the Cortex-Basal Ganglia Network After Dopamine Depletion in the Rat J Neurophysiol, July 1, 2008; 100(1): 385 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Li, G. W. Arbuthnott, M. J. Jutras, J. A. Goldberg, and D. Jaeger Resonant Antidromic Cortical Circuit Activation as a Consequence of High-Frequency Subthalamic Deep-Brain Stimulation J Neurophysiol, December 1, 2007; 98(6): 3525 - 3537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mukovski, S. Chauvette, I. Timofeev, and M. Volgushev Detection of Active and Silent States in Neocortical Neurons from the Field Potential Signal during Slow-Wave Sleep Cereb Cortex, February 1, 2007; 17(2): 400 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Humphries, R. D. Stewart, and K. N. Gurney A Physiologically Plausible Model of Action Selection and Oscillatory Activity in the Basal Ganglia J. Neurosci., December 13, 2006; 26(50): 12921 - 12942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mahon, N. Vautrelle, L. Pezard, S. J. Slaght, J.-M. Deniau, G. Chouvet, and S. Charpier Distinct Patterns of Striatal Medium Spiny Neuron Activity during the Natural Sleep-Wake Cycle J. Neurosci., November 29, 2006; 26(48): 12587 - 12595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kasanetz, L. A. Riquelme, P. O'Donnell, and M. G. Murer Turning off cortical ensembles stops striatal Up states and elicits phase perturbations in cortical and striatal slow oscillations in rat in vivo J. Physiol., November 15, 2006; 577(1): 97 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-O. Polack and S. Charpier Intracellular activity of cortical and thalamic neurones during high-voltage rhythmic spike discharge in Long-Evans rats in vivo J. Physiol., March 1, 2006; 571(2): 461 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Christophe, N. Doerflinger, D. J. Lavery, Z. Molnar, S. Charpak, and E. Audinat Two Populations of Layer V Pyramidal Cells of the Mouse Neocortex: Development and Sensitivity to Anesthetics J Neurophysiol, November 1, 2005; 94(5): 3357 - 3367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. D. Kerr, D. Greenberg, and F. Helmchen From The Cover: Imaging input and output of neocortical networks in vivo PNAS, September 27, 2005; 102(39): 14063 - 14068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Lukatch, C. E. Kiddoo, and M. B. MacIver Anesthetic-induced Burst Suppression EEG Activity Requires Glutamate-mediated Excitatory Synaptic Transmission Cereb Cortex, September 1, 2005; 15(9): 1322 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mallet, C. Le Moine, S. Charpier, and F. Gonon Feedforward Inhibition of Projection Neurons by Fast-Spiking GABA Interneurons in the Rat Striatum In Vivo J. Neurosci., April 13, 2005; 25(15): 3857 - 3869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sharott, P. J Magill, J. P. Bolam, and P. Brown Directional analysis of coherent oscillatory field potentials in the cerebral cortex and basal ganglia of the rat J. Physiol., February 1, 2005; 562(3): 951 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Y. Tseng and P. O'Donnell Post-pubertal Emergence of Prefrontal Cortical Up States Induced by D1-NMDA Co-activation Cereb Cortex, January 1, 2005; 15(1): 49 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Venance, J. Glowinski, and C. Giaume Electrical and chemical transmission between striatal GABAergic output neurones in rat brain slices J. Physiol., August 15, 2004; 559(1): 215 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Slaght, T. Paz, M. Chavez, J.-M. Deniau, S. Mahon, and S. Charpier On the Activity of the Corticostriatal Networks during Spike-and-Wave Discharges in a Genetic Model of Absence Epilepsy J. Neurosci., July 28, 2004; 24(30): 6816 - 6825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Winterer, R. Coppola, T. E. Goldberg, M. F. Egan, D. W. Jones, C. E. Sanchez, and D. R. Weinberger Prefrontal Broadband Noise, Working Memory, and Genetic Risk for Schizophrenia Am J Psychiatry, March 1, 2004; 161(3): 490 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. D. Kerr and D. Plenz Action Potential Timing Determines Dendritic Calcium during Striatal Up-States J. Neurosci., January 28, 2004; 24(4): 877 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Goldberg, S. S. Kats, and D. Jaeger Globus Pallidus Discharge Is Coincident with Striatal Activity during Global Slow Wave Activity in the Rat J. Neurosci., November 5, 2003; 23(31): 10058 - 10063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Topolnik, M. Steriade, and I. Timofeev Partial Cortical Deafferentation Promotes Development of Paroxysmal Activity Cereb Cortex, August 1, 2003; 13(8): 883 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mahon, G. Casassus, C. Mulle, and S. Charpier Spike-Dependent Intrinsic Plasticity Increases Firing Probability in Rat Striatal Neurons In Vivo J. Physiol., August 1, 2003; 550(3): 947 - 959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ramanathan, J. J. Hanley, J.-M. Deniau, and J. P. Bolam Synaptic Convergence of Motor and Somatosensory Cortical Afferents onto GABAergic Interneurons in the Rat Striatum J. Neurosci., September 15, 2002; 22(18): 8158 - 8169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kasanetz, L. A Riquelme, and M G. Murer Disruption of the two-state membrane potential of striatal neurones during cortical desynchronisation in anaesthetised rats J. Physiol., September 1, 2002; 543(2): 577 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. West, H. Moore, and A. A. Grace Direct Examination of Local Regulation of Membrane Activity in Striatal and Prefrontal Cortical Neurons in Vivo Using Simultaneous Intracellular Recording and Microdialysis J. Pharmacol. Exp. Ther., June 1, 2002; 301(3): 867 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Degenetais, A.-M. Thierry, J. Glowinski, and Y. Gioanni Electrophysiological Properties of Pyramidal Neurons in the Rat Prefrontal Cortex: An In Vivo Intracellular Recording Study Cereb Cortex, January 1, 2002; 12(1): 1 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. West and A. A. Grace Opposite Influences of Endogenous Dopamine D1 and D2 Receptor Activation on Activity States and Electrophysiological Properties of Striatal Neurons: Studies Combining In Vivo Intracellular Recordings and Reverse Microdialysis J. Neurosci., January 1, 2002; 22(1): 294 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Y. Tseng, F. Kasanetz, L. Kargieman, L. A. Riquelme, and M. G. Murer Cortical Slow Oscillatory Activity Is Reflected in the Membrane Potential and Spike Trains of Striatal Neurons in Rats with Chronic Nigrostriatal Lesions J. Neurosci., August 15, 2001; 21(16): 6430 - 6439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Goto and P. O'Donnell Network Synchrony in the Nucleus Accumbens In Vivo J. Neurosci., June 15, 2001; 21(12): 4498 - 4504. [Abstract] [Full Text] [PDF]
|
|