Cerebral Cortex, Vol. 11, No. 12, 1136-1143,
December 2001
© 2001 Oxford University Press
Enhanced or Impaired Cognitive Function in Parkinson's Disease as a Function of Dopaminergic Medication and Task Demands
Department of Experimental Psychology, University of Cambridge, Downing Street,, 1 Cambridge Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way and, 2 Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
Trevor W. Robbins, University of Cambridge, Department of Experimental Psychology, Downing Street, Cambridge CB2 3EB, UK. Email: twr2{at}cam.ac.uk.
We investigated how dopamine (DA) systems contribute to cognitive performance in the domain of learning and attentional flexibility by examining effects of withdrawing DA-ergic medication in patients with Parkinson's disease (PD). Medication remediated impairments in switching between two tasks, thought to depend on circuitry connecting the dorsolateral prefrontal cortex and the posterior parietal cortex to the dorsal caudate nucleus, which is profoundly DA-depleted in PD. By contrast, the same medication impaired probabilistic reversal learning that implicates orbitofrontal cortex– ventral striatal circuitry, which is relatively spared of DA loss in PD. Hence, DA-ergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of DA function in underlying cortico-striatal circuitry.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Bodi, S. Keri, H. Nagy, A. Moustafa, C. E. Myers, N. Daw, G. Dibo, A. Takats, D. Bereczki, and M. A. Gluck Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients Brain, September 1, 2009; 132(9): 2385 - 2395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Walsh and M. L. Phillips Interacting Outcome Retrieval, Anticipation, and Feedback Processes in the Human Brain Cereb Cortex, May 8, 2009; (2009) bhp098v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Abe, T. Fujii, K. Hirayama, A. Takeda, Y. Hosokai, T. Ishioka, Y. Nishio, K. Suzuki, Y. Itoyama, S. Takahashi, et al. Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behaviour Brain, May 1, 2009; 132(5): 1386 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Clatworthy, S. J. G. Lewis, L. Brichard, Y. T. Hong, D. Izquierdo, L. Clark, R. Cools, F. I. Aigbirhio, J.-C. Baron, T. D. Fryer, et al. Dopamine Release in Dissociable Striatal Subregions Predicts the Different Effects of Oral Methylphenidate on Reversal Learning and Spatial Working Memory J. Neurosci., April 15, 2009; 29(15): 4690 - 4696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Jocham, T. A. Klein, J. Neumann, D. Y. von Cramon, M. Reuter, and M. Ullsperger Dopamine DRD2 Polymorphism Alters Reversal Learning and Associated Neural Activity J. Neurosci., March 25, 2009; 29(12): 3695 - 3704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Zaghloul, J. A. Blanco, C. T. Weidemann, K. McGill, J. L. Jaggi, G. H. Baltuch, and M. J. Kahana Human Substantia Nigra Neurons Encode Unexpected Financial Rewards Science, March 13, 2009; 323(5920): 1496 - 1499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cools, M. J. Frank, S. E. Gibbs, A. Miyakawa, W. Jagust, and M. D'Esposito Striatal Dopamine Predicts Outcome-Specific Reversal Learning and Its Sensitivity to Dopaminergic Drug Administration J. Neurosci., February 4, 2009; 29(5): 1538 - 1543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ragland, R. Cools, M. Frank, D. A. Pizzagalli, A. Preston, C. Ranganath, and A. D. Wagner CNTRICS Final Task Selection: Long-Term Memory Schizophr Bull, January 1, 2009; 35(1): 197 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. Murray, F. Cheng, L. Clark, J. H. Barnett, A. D. Blackwell, P. C. Fletcher, T. W. Robbins, E. T. Bullmore, and P. B. Jones Reinforcement and Reversal Learning in First-Episode Psychosis Schizophr Bull, September 1, 2008; 34(5): 848 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Rowe, L. Hughes, B. C. P. Ghosh, D. Eckstein, C. H. Williams-Gray, S. Fallon, R. A. Barker, and A. M. Owen Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition Brain, August 1, 2008; 131(8): 2094 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M K York, M Dulay, A Macias, H S Levin, R Grossman, R Simpson, and J Jankovic Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson's disease J. Neurol. Neurosurg. Psychiatry, July 1, 2008; 79(7): 789 - 795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Dodds, U. Muller, L. Clark, A. van Loon, R. Cools, and T. W. Robbins Methylphenidate Has Differential Effects on Blood Oxygenation Level-Dependent Signal Related to Cognitive Subprocesses of Reversal Learning J. Neurosci., June 4, 2008; 28(23): 5976 - 5982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bellebaum, B. Koch, M. Schwarz, and I. Daum Focal basal ganglia lesions are associated with impairments in reward-based reversal learning Brain, March 1, 2008; 131(3): 829 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Williams-Gray, A. Hampshire, R. A. Barker, and A. M. Owen Attentional control in Parkinson's disease is dependent on COMT val158met genotype Brain, February 1, 2008; 131(2): 397 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cools, S. E. Gibbs, A. Miyakawa, W. Jagust, and M. D'Esposito Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum J. Neurosci., January 30, 2008; 28(5): 1208 - 1212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Westermann, E Wattendorf, U Schwerdtfeger, A Husner, P Fuhr, O Gratzl, T Hummel, D Bilecen, and A Welge-Lussen Functional imaging of the cerebral olfactory system in patients with Parkinson's disease J. Neurol. Neurosurg. Psychiatry, January 1, 2008; 79(1): 19 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J Frank, A. Scheres, and S. J Sherman Understanding decision-making deficits in neurological conditions: insights from models of natural action selection Phil Trans R Soc B, September 29, 2007; 362(1485): 1641 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Williams-Gray, T. Foltynie, C. E. G. Brayne, T. W. Robbins, and R. A. Barker Evolution of cognitive dysfunction in an incident Parkinson's disease cohort Brain, July 1, 2007; 130(7): 1787 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J Hood, S. C Amador, A. E Cain, K. A Briand, A. H Al-Refai, M. C Schiess, and A. B Sereno Levodopa slows prosaccades and improves antisaccades: an eye movement study in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, June 1, 2007; 78(6): 565 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.W Robbins Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications Phil Trans R Soc B, May 29, 2007; 362(1481): 917 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cools, M. Sheridan, E. Jacobs, and M. D'Esposito Impulsive Personality Predicts Dopamine-Dependent Changes in Frontostriatal Activity during Component Processes of Working Memory J. Neurosci., May 16, 2007; 27(20): 5506 - 5514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Clarke, S. Walker, J. Dalley, T. Robbins, and A. Roberts Cognitive Inflexibility after Prefrontal Serotonin Depletion Is Behaviorally and Neurochemically Specific Cereb Cortex, January 1, 2007; 17(1): 18 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Seger The Basal Ganglia in Human Learning Neuroscientist, August 1, 2006; 12(4): 285 - 290. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Ito and J. Kitagawa Performance Monitoring and Error Processing During a Lexical Decision Task in Patients With Parkinson's Disease J Geriatr Psychiatry Neurol, March 1, 2006; 19(1): 46 - 54. [Abstract] [PDF]
|
|
|
|
|
|
A L Cheesman, R A Barker, S J G Lewis, T W Robbins, A M Owen, and D J Brooks Lateralisation of striatal function: evidence from 18F-dopa PET in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, September 1, 2005; 76(9): 1204 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pessiglione, D. Guehl, A.-S. Rolland, C. Francois, E. C. Hirsch, J. Feger, and L. Tremblay Thalamic Neuronal Activity in Dopamine-Depleted Primates: Evidence for a Loss of Functional Segregation within Basal Ganglia Circuits J. Neurosci., February 9, 2005; 25(6): 1523 - 1531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Muller, E. Mottweiler, and P. Bublak Noradrenergic blockade and numeric working memory in humans J Psychopharmacol, January 1, 2005; 19(1): 21 - 28. [Abstract] [PDF]
|
|
|
|
|
|
M. J. Frank, L. C. Seeberger, and R. C. O'Reilly By Carrot or by Stick: Cognitive Reinforcement Learning in Parkinsonism Science, December 10, 2004; 306(5703): 1940 - 1943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Owen Cognitive Dysfunction in Parkinson's Disease: The Role of Frontostriatal Circuitry Neuroscientist, December 1, 2004; 10(6): 525 - 537. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Hershey, F. J. Revilla, A. Wernle, P. S. Gibson, J. L. Dowling, and J. S. Perlmutter Stimulation of STN impairs aspects of cognitive control in PD Neurology, April 13, 2004; 62(7): 1110 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Shohamy, C. E. Myers, S. Grossman, J. Sage, M. A. Gluck, and R. A. Poldrack Cortico-striatal contributions to feedback-based learning: converging data from neuroimaging and neuropsychology Brain, April 1, 2004; 127(4): 851 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Escola, Th. Michelet, F. Macia, D. Guehl, B. Bioulac, and P. Burbaud Disruption of information processing in the supplementary motor area of the MPTP-treated monkey: A clue to the pathophysiology of akinesia? Brain, January 1, 2003; 126(1): 95 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cools, L. Clark, A. M. Owen, and T. W. Robbins Defining the Neural Mechanisms of Probabilistic Reversal Learning Using Event-Related Functional Magnetic Resonance Imaging J. Neurosci., June 1, 2002; 22(11): 4563 - 4567. [Abstract] [Full Text] [PDF]
|
|