Cerebral Cortex, Vol. 10, No. 3, 334-342,
March 2000
© 2000 Oxford University Press
Orbitofrontal Cortex and Human Drug Abuse: Functional Imaging
Brain Imaging Center, National Institute on Drug Abuse, Baltimore, MD 21224, USA
The orbitofrontal cortex (OFC) plays a central role in human behavior. Anatomically connected with association areas of all sensory modalities, limbic structures, prefrontal cortical regions that mediate executive function and subcortical nuclei, this brain region can serve to integrate the physical and emotional attributes of a stimulusobject and establish a motivational value based on estimation of potential reward. To the extent that addictive disorders reflect a dysregulation of the ability to evaluate potential reward against harm from drug self-administration, it would be anticipated that substance abuse disorder might reflect dysfunction of the OFC. With the application of brain imaging techniques to the study of human substance abuse, evidence has been obtained that activity in the OFC and its connections plays a role in several components of the maladaptive behavior of substance abuse, including expectancy, craving and impaired decision making.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. M. Syngelaki, S. C. Moore, J. C. Savage, G. Fairchild, and S. H.M. Van Goozen Executive Functioning and Risky Decision Making in Young Male Offenders Criminal Justice and Behavior, November 1, 2009; 36(11): 1213 - 1227. [Abstract] [PDF]
|
|
|
|
 |
|
 C. A. Boettiger, J. M. Mitchell, V. C. Tavares, M. Robertson, G. Joslyn, M. D'Esposito, and H. L. Fields Immediate Reward Bias in Humans: Fronto-Parietal Networks and a Role for the Catechol-O-Methyltransferase 158Val/Val Genotype J. Neurosci., December 26, 2007; 27(52): 14383 - 14391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-O. H. Wikstrom and K. Treiber The Role of Self-Control in Crime Causation: Beyond Gottfredson and Hirschi's General Theory of Crime European Journal of Criminology, April 1, 2007; 4(2): 237 - 264. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Weinstein and W. M. Cox Cognitive processing of drug-related stimuli: the role of memory and attention J Psychopharmacol, November 1, 2006; 20(6): 850 - 859. [Abstract] [PDF]
|
|
|
|
 |
|
 S. L. Ames and C. McBride Translating Genetics, Cognitive Science, and Other Basic Science Research Findings Into Applications for Prevention Eval Health Prof, September 1, 2006; 29(3): 277 - 301. [Abstract] [PDF]
|
|
|
|
|
|
H. Homayoun and B. Moghaddam Progression of Cellular Adaptations in Medial Prefrontal and Orbitofrontal Cortex in Response to Repeated Amphetamine J. Neurosci., August 2, 2006; 26(31): 8025 - 8039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fumal, S. Laureys, L. Di Clemente, M. Boly, V. Bohotin, M. Vandenheede, G. Coppola, E. Salmon, R. Kupers, and J. Schoenen Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine Brain, February 1, 2006; 129(2): 543 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Markon and R. F. Krueger Categorical and Continuous Models of Liability to Externalizing Disorders: A Direct Comparison in NESARC Arch Gen Psychiatry, December 1, 2005; 62(12): 1352 - 1359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Dom, B. Sabbe, W. Hulstijn, and W. van den Brink Substance use disorders and the orbitofrontal cortex: Systematic review of behavioural decision-making and neuroimaging studies The British Journal of Psychiatry, September 1, 2005; 187(3): 209 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Schoenbaum and B. Setlow Cocaine Makes Actions Insensitive to Outcomes but not Extinction: Implications for Altered Orbitofrontal-Amygdalar Function Cereb Cortex, August 1, 2005; 15(8): 1162 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Paulus, S. F. Tapert, and M. A. Schuckit Neural Activation Patterns of Methamphetamine-Dependent Subjects During Decision Making Predict Relapse Arch Gen Psychiatry, July 1, 2005; 62(7): 761 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Crombag, G. Gorny, Y. Li, B. Kolb, and T. E. Robinson Opposite Effects of Amphetamine Self-administration Experience on Dendritic Spines in the Medial and Orbital Prefrontal Cortex Cereb Cortex, March 1, 2005; 15(3): 341 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sawamura, T. Sawamura-Yamamoto, Y. Ozeki, C. A. Ross, and A. Sawa A form of DISC1 enriched in nucleus: Altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse PNAS, January 25, 2005; 102(4): 1187 - 1192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tateno, R. E. Jorge, and R. G. Robinson Pathological Laughing and Crying Following Traumatic Brain Injury J Neuropsychiatry Clin Neurosci, November 1, 2004; 16(4): 426 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Fuchs, K. A. Evans, M. P. Parker, and R. E. See Differential Involvement of Orbitofrontal Cortex Subregions in Conditioned Cue-Induced and Cocaine-Primed Reinstatement of Cocaine Seeking in Rats J. Neurosci., July 21, 2004; 24(29): 6600 - 6610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pears, J. A. Parkinson, L. Hopewell, B. J. Everitt, and A. C. Roberts Lesions of the Orbitofrontal but not Medial Prefrontal Cortex Disrupt Conditioned Reinforcement in Primates J. Neurosci., December 3, 2003; 23(35): 11189 - 11201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tateno, R. E. Jorge, and R. G. Robinson Clinical Correlates of Aggressive Behavior After Traumatic Brain Injury J Neuropsychiatry Clin Neurosci, May 1, 2003; 15(2): 155 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Brody, M. A. Mandelkern, E. D. London, A. R. Childress, G. S. Lee, R. G. Bota, M. L. Ho, S. Saxena, L. R. Baxter Jr, D. Madsen, et al. Brain Metabolic Changes During Cigarette Craving Arch Gen Psychiatry, December 1, 2002; 59(12): 1162 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Perlstein, T. Elbert, and V. A. Stenger Dissociation in human prefrontal cortex of affective influences on working memory-related activity PNAS, January 24, 2002; (2002) 241650598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R.C. Daglish, A. Weinstein, A. L. Malizia, S. Wilson, J. K. Melichar, S. Britten, C. Brewer, A. Lingford-Hughes, J. S. Myles, P. Grasby, et al. Changes in Regional Cerebral Blood Flow Elicited by Craving Memories in Abstinent Opiate-Dependent Subjects Am J Psychiatry, October 1, 2001; 158(10): 1680 - 1686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. H. Gawin The Scientific Exegesis of Desire: Neuroimaging Crack Craving Arch Gen Psychiatry, April 1, 2001; 58(4): 342 - 344. [Full Text] [PDF]
|
|
|
|
|
|
B. Adinoff, M. D. Devous Sr., S. M. Best, M. S. George, D. Alexander, and K. Payne Limbic Responsiveness to Procaine in Cocaine-Addicted Subjects Am J Psychiatry, March 1, 2001; 158(3): 390 - 398. [Abstract] [Full Text]
|
|
|
|
|
|
W. M. Perlstein, T. Elbert, and V. A. Stenger Dissociation in human prefrontal cortex of affective influences on working memory-related activity PNAS, February 5, 2002; 99(3): 1736 - 1741. [Abstract] [Full Text] [PDF]
|
|