Cerebral Cortex, Vol. 9, No. 8, 765-775,
December 1999
© 1999 Oxford University Press
Feature Article: What is a Cajal–Retzius cell? A Reassessment of a Classical Cell Type Based on Recent Observations in the Developing Neocortex
Departamento de Anatomía, Universidad de La Laguna, 38071 Tenerife, Spain, , 1 Neurobiology Unit, FUNDP Medical School, B5000 Namur, Belgium and , 2 Instituto de Neurociencias, CSIC, Universidad Miguel Hernández, 03550 San Juan de Alicante, Spain
Address correspondence to Dr Gundela Meyer, Departamento de Anatomía, Facultad de Medicina, Universidad de La Laguna, 38071 La Laguna, Tenerife, Spain. Email: gmeyer@ull.es.
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The Need for a Revised Definition of the ‘Cajal–Retzius cell' |
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The term ‘Cajal–Retzius cell' is applied to neurons of the human embryonic marginal zone which display, as a salient feature, radial ascending processes that contact the pial surface, and a horizontal axon plexus located in the deep marginal zone. These cells were first described by Retzius (Retzius, 1893
, 1894) (see the cell labelled ‘Retzius, 1893' in Fig. 1). There is consensus that homologous elements are present in the non-primate neocortex, where their morphology is much simpler, as initially described in 1891 by Cajal (Fig. 2) (Cajal, 1891). In spite of several reviews (Duckett and Pease, 1968; König, 1978; Huntley and Jones, 1990; Marín-Padilla, 1978, 1990; Supèr et al., 1998), the definition of these cells has remained somewhat confusing, in part because Cajal and Retzius studied different species and different developmental stages, and also because their original publications have |
The Cells Described by Retzius and Cajal in the Human MZ Differ in their Morphology and Developmental Kinetics |
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Late-generated Retzius Cells and Cajal Cells Could Migrate Tangentially via the Subpial Granular Layer |
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The Reelin-producing Cells of the Non-primate Marginal Zone |
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The Reelin-negative Pioneer Neurons of the Marginal Zone |
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Acknowledgments |
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References |
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