Skip Navigation


Cerebral Cortex Advance Access originally published online on April 22, 2009
Cerebral Cortex 2009 19(7):1490-1492; doi:10.1093/cercor/bhp089
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
19/7/1490    most recent
bhp089v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Brenman, J. E.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brenman, J. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Fragile X Mental Retardation Protein in the Driver's Seat

Jay E. Brenman

Department of Cell and Developmental Biology and Neuroscience Center, UNC Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA

Address correspondence to Dr Jay E. Brenman. Email: brenman@med.unc.edu.

Key Words: autism • FMRP • fmr1 • Fragile X • GABA • mental retardation • mGluR5

The first 10% of the full text of this article appears below.

Fragile X syndrome (FXS), the most common single gene cause of mental retardation, is securely associated with mutations in the fragile X mental retardation 1 gene, FMR1 (Fu et al. 1991Go; Verkerk et al. 1991Go; Feng et al. 1997Go; Musumeci et al. 1999Go; Hagerman et al. 2009Go). Nevertheless, identification of consequences of loss of the protein product of FMR1, the fragile X mental retardation protein FMRP, has proven difficult. In this issue of Cerebral Cortex, 2 papers, one by Curia et al. and the other by Qiu et al., demonstrate that FMRP normally navigates the treacherous road of hippocampal excitation and inhibition, controlling the {gamma}-aminobutyric acidergic (GABAergic) brakes and glutamatergic . . . [Full Text of this Article]


   Funding
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?