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Cerebral Cortex November 2003; 13:1123
© Oxford University Press 2003

Persistent Neural Activity: Experiments and Theory

Xiao-Jing Wang

Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 USA

The first 10% of the full text of this article appears below.

The ability of neurons to generate persistent activity in the absence of stimulation is of fundamental importance to complex behaviors. Deprived of this faculty, our brain would be completely at the mercy of sensory inputs of the moment; there would be no internal state of the mind, nor association and integration across time. Higher cognitive processes, such as working memory, decision-making or goal-directed behavior, would be impossible.

Since Niki in Japan and Fuster in the USA published their seminal papers in 1971, neurophysiologists have documented memory-related persistent activity in many brain regions. Only . . . [Full Text of this Article]


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