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Cerebral Cortex Advance Access published online on October 13, 2009
Cerebral Cortex, doi:10.1093/cercor/bhp226
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© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Feature article

Profiles of Precentral and Postcentral Cortical Mean Thicknesses in Individual Subjects over Acute and Subacute Time-Scales

Xin Wang1,2, Mischka Gerken1, Michael Dennis3, Richard Mooney1, John Kane4, Sadik Khuder5, Hong Xie1, William Bauer1, A. Vania Apkarian6,7 and John Wall1

1 Department of Neurosciences, 2 Department of Psychiatry, 3 Department of Radiology, 4 Department of Orthopedics, 5 Department of Medicine, University of Toledo Medical Center, Toledo, OH 43614, USA, 6 Department of Physiology, Anesthesia, and Surgery, Northwestern University Medical School, Chicago, IL 60611, USA, 7 Neuroscience Institute, Northwestern University Medical School, Chicago, IL 60611, USA

Address correspondence to John Wall. Email: john.wall{at}utoledo.edu.

Human precentral and postcentral cortical areas interact to generate sensorimotor functions. Recent imaging work suggests that pre- and postcentral cortical thicknesses of an individual vary over time-scales of years and decades due to aging, disease, and other factors. In contrast, there is little understanding of how thicknesses of these areas vary in an individual over time-scales of minutes and weeks. This study used longitudinal magnetic resonance imaging (MRI) and computational morphometry approaches in 5 healthy subjects to assess how mean thicknesses, and intra- and interhemispheric relationships in mean thicknesses, of these areas vary in an individual subject over minutes and weeks. Within each individual, absolute differences in thicknesses over these times were small and similar in the precentral (mean = 0.02–0.04 mm) and postcentral (mean = 0.03–0.05 mm) areas. Each individual also had a consistent intrahemispheric disparity and interhemispheric asymmetrical or symmetrical relationship in thicknesses of these areas over these times. The results provide new understanding of within-individual cortical thickness variability in these areas and raise the possibility that longitudinal thickness profiling can provide a baseline definition of short time-scale thickness variability that can be used to detect acute and subacute changes in pre- and postcentral thicknesses at an individual subject level.

Key Words: interhemispheric • intrahemispheric • longitudinal • magnetic resonance imaging • sensorimotor cortex


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