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Cerebral Cortex Advance Access published online on August 17, 2009
Cerebral Cortex, doi:10.1093/cercor/bhp160
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© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Activity in Preserved Left Hemisphere Regions Predicts Anomia Severity in Aphasia

Julius Fridriksson1, Leonardo Bonilha2, Julie M. Baker1, Dana Moser1 and Chris Rorden1

1 Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA, 2 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA

Address correspondence to Dr Julius Fridriksson, PhD, University of South Carolina, Department of Communication Sciences and Disorders, Columbia, SC 29208. E-mail: jfridrik{at}sc.edu.

Understanding the neural mechanism that supports preserved language processing in aphasia has implications for both basic and applied science. This study examined brain activation associated with correct picture naming in 15 patients with aphasia. We contrasted each patient's activation to the activation observed in a neurologically healthy control group, allowing us to identify regions with unusual activity patterns. The results revealed that increased activation in preserved left hemisphere areas is associated with better naming performance in aphasia. This relationship was linear in nature; progressively less cortical activation was associated with greater severity of anomia. These findings are consistent with others who suggests that residual language function following stroke relies on preserved cortical areas in the left hemisphere.

Key Words: brain plasticity • fMRI • neuroimaging • recovery • stroke


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