Skip Navigation



Cerebral Cortex Advance Access published online on May 6, 2009
Cerebral Cortex, doi:10.1093/cercor/bhp085
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Sabuncu, M. R.
Right arrow Articles by Haxby, J. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sabuncu, M. R.
Right arrow Articles by Haxby, J. V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2009 The Authors
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Function-based Intersubject Alignment of Human Cortical Anatomy

Mert R. Sabuncu1,2, Benjamin D. Singer3, Bryan Conroy1, Ronald E. Bryan4,5, Peter J. Ramadge1 and James V. Haxby4,6,7

1 Department of Electrical Engineering, Princeton University, Princeton, NJ 08544, USA, 2 Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA 02138, USA, 3 Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA, 4 Department of Psychology, Princeton University, Princeton, NJ 08544, USA, 5 Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA, 6 Center for Cognitive Neuroscience, Dartmouth College, Hanover, NH 03755, USA, 7 Department of Psychological & Brain Sciences, Dartmouth College, Hanover, NH 03755, USA

Address correspondence to James V. Haxby, PhD, Department of Psychological & Brain Sciences, Dartmouth College, Hanover, NH 03755, USA. Email: james.v.haxby{at}dartmouth.edu.

Making conclusions about the functional neuroanatomical organization of the human brain requires methods for relating the functional anatomy of an individual's brain to population variability. We have developed a method for aligning the functional neuroanatomy of individual brains based on the patterns of neural activity that are elicited by viewing a movie. Instead of basing alignment on functionally defined areas, whose location is defined as the center of mass or the local maximum response, the alignment is based on patterns of response as they are distributed spatially both within and across cortical areas. The method is implemented in the two-dimensional manifold of an inflated, spherical cortical surface. The method, although developed using movie data, generalizes successfully to data obtained with another cognitive activation paradigm—viewing static images of objects and faces—and improves group statistics in that experiment as measured by a standard general linear model (GLM) analysis.

Key Words: between-subject alignment • fMRI • human cortex • neuroimaging

Mert R. Sabuncu and Benjamin D. Singer contributed equally to this work.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.