Skip Navigation



Cerebral Cortex Advance Access published online on January 15, 2009
Cerebral Cortex, doi:10.1093/cercor/bhn227
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow All Versions of this Article:
19/9/2092    most recent
bhn227v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Tabata, H.
Right arrow Articles by Nakajima, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tabata, H.
Right arrow Articles by Nakajima, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Differences of Migratory Behavior between Direct Progeny of Apical Progenitors and Basal Progenitors in the Developing Cerebral Cortex

Hidenori Tabata, Shigeaki Kanatani and Kazunori Nakajima

Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

Address correspondence to Kazunori Nakajima, MD, PhD, Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Email: kazunori{at}sc.itc.keio.ac.jp.

Cerebral cortical neurons are known to be produced from both apical progenitors in the ventricular zone (VZ) and basal (intermediate) progenitors in the subventricular zone (SVZ). On the other hand, we have shown that many SVZ cells assume multipolar morphology and show a characteristic movement termed "multipolar migration." The relationship between multipolar cells and basal progenitors in the SVZ has yet to be investigated. Herein, we followed postmitotic cells generated in the VZ and found that they stayed for more than 10 h in the VZ after becoming postmitotic and then accumulated in the lower part of the SVZ (multipolar cell accumulation zone: MAZ) as multipolar cells (slowly exiting population: SEP), whereas basal progenitors rapidly migrated into the SVZ or intermediate zone (IZ) (rapidly exiting population: REP) with somal translocation morphology. Although REP reached the SVZ/IZ earlier than the SEP, REP stayed within in the SVZ/IZ, whereas SEP moved steadily and entered the CP prior to the REP. We also observed SEP to eventually differentiate into pyramidal neurons in layers II/III. This study provides in vivo evidence of differences in migration modes between postmitotic cells generated from apical progenitors and basal progenitors.

Key Words: cerebral cortex • mouse • multipolar cell accumulation zone (MAZ) • multipolar migration • subventricular zone


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.