Skip Navigation



Cerebral Cortex Advance Access published online on November 19, 2008
Cerebral Cortex, doi:10.1093/cercor/bhn212
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
19/8/1820    most recent
bhn212v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Glausier, J. R.
Right arrow Articles by Muly, E. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Glausier, J. R.
Right arrow Articles by Muly, E. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Dopamine D1 and D5 Receptors Are Localized to Discrete Populations of Interneurons in Primate Prefrontal Cortex

Jill R. Glausier1,2, Zafar U. Khan3 and E. Chris Muly1,2,4

1 Division of Neuroscience, Yerkes National Primate Research Center, Atlanta, GA 30329, USA, 2 Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA, 3 Laboratory of Neurobiology, Centro de Investigaciones Medico-Sanitarias (CIMES), Faculty of Medicine, University of Malaga, Malaga, Spain, 4 Department of Veterans Affairs Medical Center, Decatur, Atlanta, GA 30033, USA

Address correspondence to email: emuly{at}emory.edu.

Working memory (WM) is a core cognitive process that depends upon activation of D1 family receptors (D1R) and inhibitory interneurons in the prefrontal cortex (PFC). D1R are comprised of the D1 and D5 subtypes, and D5 has a 10-fold higher affinity for dopamine. Parvalbumin (PV) and calretinin (CR) are 2 interneuron populations that are differentially affected by D1R stimulation and have discrete postsynaptic targets, such that PV interneurons provide strong inhibition to pyramidal cells, whereas CR interneurons inhibit other interneurons. The distinct properties of both the D1R and interneuron subtypes may contribute to the "inverted-U" relationship of D1R stimulation and WM ability. To determine the prevalence of D1 and D5 in PV and CR interneurons, we performed quantitative double-label immunoelectron microscopy in layer III of macaque area 9. We found that D1 was the predominant D1R subtype in PV interneurons and was found mainly in dendrites. In contrast, D5 was the predominant D1R subtype in CR interneurons and was found mainly in dendrites. Integrating these findings with previously published electrophysiological data, we propose a circuitry model as a framework for understanding the inverted-U relationship between dopamine stimulation of D1R and WM performance.

Key Words: calretinin • electron microscopy • parvalbumin • synapses • working memory


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.