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Cerebral Cortex Advance Access published online on July 31, 2008
Cerebral Cortex, doi:10.1093/cercor/bhn124
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Delineation of the Middle Longitudinal Fascicle in Humans: A Quantitative, In Vivo, DT-MRI Study

Nikos Makris1,2, George M. Papadimitriou1, Jonathan R. Kaiser1, Scott Sorg1, David N. Kennedy1 and Deepak N. Pandya2

1 Harvard Medical School Departments of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA, 2 Boston University School of Medicine, Department of Anatomy and Neurobiology, Boston, MA 02215, USA

Address correspondence to Nikos Makris, MD, PhD, Massachusetts General Hospital, Center for Morphometric Analysis, Building 149, 13th Street, Charlestown, MA 02129, USA. Email: nikos{at}cma.mgh.harvard.edu.

Experimental and imaging studies in monkeys have outlined various long association fiber bundles within the temporoparietal region. In the present study the trajectory of the middle longitudinal fascicle (MdLF) has been delineated in 4 human subjects using diffusion tensor magnetic resonance imaging segmentation and tractography. The MdLF seems to extend from the inferior parietal lobule (IPL), specifically the angular gyrus, to the temporal pole remaining within the white matter of the superior temporal gyrus (STG). Comparison of the superior longitudinal fascicle II-arcuate fascicle (SLF II-AF) with the MdLF in the same subjects revealed that MdLF is located in a medial and caudal position relative to SLF II-AF and that it extends more rostrally. Given the location of MdLF between the IPL (angular gyrus) and the STG, it is suggested that MdLF could have a role in language and attention functions.

Key Words: DT-MRI • middle longitudinal fascicle • segmentation • tractography

Human Research Statement: The experiments undertaken in this paper were performed with the understanding and written informed consent of each subject.


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