Cerebral Cortex Advance Access published online on February 21, 2008
Cerebral Cortex, doi:10.1093/cercor/bhn014
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Functional Coactivation Map of the Human Brain
Paus1,31 Brain & Body Centre, University of Nottingham, Nottingham NG7 2RD, United Kingdom, 2 Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA, 3 Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
Address correspondence to Roberto Toro, PhD, Brain & Body Centre, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom. Email: rto{at}psychology.nottingham.ac.uk.
Understanding the interactions among different brain regions is fundamental to our understanding of brain function. Here we describe a complete map of functional connections in the human brain derived by an automatic meta-analysis of 825 neuroimaging articles, representing 3402 experiments. The likelihood of a functional connection between regions was estimated by studying the interdependence of their "activity," as reported in each experiment, across all experiments. We obtained a dense coactivation map that recovers some fundamental principles of the brain's functional connectivity, such as the symmetric interhemispheric connections, and important functional networks, such as the fronto-parietal attention network, the resting state network and the motor network.
Key Words: brain mapping database functional connectivity human brain meta-analysis