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Cerebral Cortex Advance Access published online on January 31, 2008
Cerebral Cortex, doi:10.1093/cercor/bhm241
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Probabilistic Maps, Morphometry, and Variability of Cytoarchitectonic Areas in the Human Superior Parietal Cortex

Filip Scheperjans1,2, Simon B. Eickhoff1, Lars Hömke1, Hartmut Mohlberg1, Klaudia Hermann1,2, Katrin Amunts1,3 and Karl Zilles1,2

1 Institute of Medicine, Research Center Jülich, D-52425 Jülich, Germany, 2 C. & O. Vogt Institute for Brain Research, University of Düsseldorf, D-40001 Düsseldorf, Germany, 3 Department of Psychiatry and Psychotherapy, Aachen University Hospital, D-52074 Aachen, Germany

Address correspondence to Filip Scheperjans, Institute of Medicine, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany. Email: filip{at}gmx.net.

Recently, 8 areas (5Ci, 5M, 5L, 7PC, 7A, 7P, 7M, hIP3) in the human superior parietal cortex (SPC) were delineated in 10 postmortem brains using observer-independent cytoarchitectonic analysis. Here we present 3D probabilistic maps of these areas, quantifying the interindividual overlap for each voxel in stereotaxic reference space, and a maximum probability map, providing a contiguous parcellation. For all areas, we determined probabilities of mutual borders, calculated stereotaxic centers of gravity, and estimated volumes. A basic pattern of areas and borders was observed, which showed, however, intersubject variations and a significant interhemispheric asymmetry (7P, 7M) that may be functionally relevant. There was a trend toward higher intersubject anatomical variability in lateral compared with medial areas. For several areas (5M, 7PC, 7A, 7P), variability was significantly higher in the left hemisphere and/or in men, whereas for areas 5Ci and 5M there was a hemisphere-by-gender interaction. Differences in anatomical variability could bias group analyses in functional imaging studies by reducing sensitivity for activations of entities with high variability. The probabilistic maps provide an objective anatomical reference and account for the structural variability of the human brain. Integrated into functional imaging experiments, they can improve structure–function investigations of the human SPC.

Key Words: area 5 • area 7 • brain mapping • intraparietal sulcus (IPS) • precuneus • superior parietal lobule (SPL)


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