Skip Navigation



Cerebral Cortex Advance Access published online on December 28, 2007
Cerebral Cortex, doi:10.1093/cercor/bhm238
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Faedo, A.
Right arrow Articles by Rubenstein, J. L. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Faedo, A.
Right arrow Articles by Rubenstein, J. L. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

COUP-TFI Coordinates Cortical Patterning, Neurogenesis, and Laminar Fate and Modulates MAPK/ERK, AKT, and ß-Catenin Signaling

Andrea Faedo1, Giulio Srubek Tomassy2, Youlin Ruan1, Hannah Teichmann2, Stefan Krauss3, Samuel J. Pleasure4, Sophia Y. Tsai5, Ming-Jer Tsai5, Michèle Studer2 and John L. R. Rubenstein1

1 Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94158, USA, 2 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Napoli, Italy, 3 Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, University of Oslo, The National Hospital, 0027 Oslo, Norway, 4 Department of Neurology, Programs in Neuroscience and Developmental Biology, University of California, San Francisco, CA 94158, USA, 5 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA

Address correspondence to Andrea Faedo, Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA. Email: andrea.faedo{at}ucsf.edu.

A major unsolved question in cortical development is how proliferation, neurogenesis, regional growth, regional identity, and laminar fate specification are coordinated. Here we provide evidence, using loss-of-function and gain-of-function manipulations, that the COUP-TFI orphan nuclear receptor promotes ventral cortical fate, promotes cell cycle exit and neural differentiation, regulates the balance of early- and late-born neurons, and regulates the balanced production of different types of layer V cortical projection neurons. We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and β-catenin signaling.

Key Words: β-catenin • COUP-TFI • Mapk/Erk • neurogenesis • PI3K/Akt • proliferation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.