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Cerebral Cortex, Vol. 9, No. 8, 896-901, December 1999
© 1999 Oxford University Press

Sex Differences in the Inferior Parietal Lobule

Melissa E. Frederikse1, Angela Lu1, Elizabeth Aylward1,2, Patrick Barta1 and Godfrey Pearlson1

1 Division of Psychiatric Neuro-Imaging, Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 and , 2 Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, USA

Address correspondence to Godfrey D. Pearlson, MD, Division of Psychiatric Neuro-Imaging, Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. Email: godfr{at}jhmi.edu.

The inferior parietal lobule (IPL) – a neocortical region and part of the heteromodal association cortex (HASC) – has been hypothesized to exhibit sexual dimorphism, as do other HASC regions, particularly with regard to asymmetry. Using a reliable method for measuring IPL gray matter volume based upon individual sulcal–gyral landmarks, we measured this region on magnetic resonance imaging scans from a sample of 15 individually matched pairs of normal male and female subjects. Male subjects showed significantly larger left, but not right, IPL volumes when compared to females. Males also showed a leftward (left > right) asymmetry for the IPL, with a less marked opposite asymmetry in females. Such sexual dimorphisms may possibly underlie the subtle cognitive differences observed between the sexes.


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