Cerebral Cortex, Vol. 9, No. 6, 524-532,
September 1999
© 1999 Oxford University Press
Genetic Control of Cortical Regionalization and Connectivity
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience, Developmental Biology and Biomedical Sciences, 401 Parnassus Avenue, University of California at San Francisco, CA 94143–0984, USA and , 1 Tigem – Telethon Institute of Genetics and Medicine, Via Olgettina 58, 20132 Milan, Italy
Herein, the genetic control of regionalization and connectivity of the neocortex are reviewed. Evidence is accumulating which suggests that intrinsic mechanisms have a central role in controlling cortical regional specification and differentiation. Expression patterns of several genes (Id-2, Tbr-1, cadherin-6, cadherin-8, neuropilin-2, Wnt-7b, Eph-A7 and RZR-beta) are described; the expressions of these genes have regional boundaries which demarcate distint functional areas of the cerebral cortex in neonatal mice.
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