Cerebral Cortex, Vol. 9, No. 4, 379-391,
June 1999
© 1999 Oxford University Press
The Functional Neuroanatomy of Novelty Processing: Integrating ERP and fMRI Results
Max-Planck-Institute of Cognitive Neuroscience, Leipzig, Germany
Recent research indicates that non-tonal novel events, deviating from an ongoing auditory environment, elicit a positive event-related potential (ERP), the novel P3. Although a variety of studies examined the neural network engaged in novelty detection, there is no complete picture of the underlying brain mechanisms. This experiment investigated these neural mechanisms by combining ERP and functional magnetic resonance imaging (fMRI). Hemodynamic and electrophysiological responses were measured in the same subjects using the same experimental design. The ERP analysis revealed a novel P3, while the fMRI responses showed bilateral foci in the middle part of the superior temporal gyrus. When subjects attended to the novel stimuli only identifiable novel sounds evoked a N4-like negativity. Subjects showing a strong N4-effect had additional fMRI activation in right prefrontal cortex (rPFC) as compared to subjects with a weak N4-effect. This pattern of results suggests that novelty processing not only includes the registration of deviancy but may also lead to a fast access and retrieval of related semantic concepts. The fMRI activation pattern suggests that the superior temporal gyrus is involved in novelty detection, whereas accessing and retrieving semantic concepts related to novel sounds additionally engages the rPFC.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Gomot, M. K. Belmonte, E. T. Bullmore, F. A. Bernard, and S. Baron-Cohen Brain hyper-reactivity to auditory novel targets in children with high-functioning autism Brain, September 1, 2008; 131(9): 2479 - 2488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Lewis, S. G. Goto, and L. L. Kong Culture and Context: East Asian American and European American Differences in P3 Event-Related Potentials and Self-Construal Pers Soc Psychol Bull, May 1, 2008; 34(5): 623 - 634. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Bunzeck, H. Schutze, S. Stallforth, J. Kaufmann, S. Duzel, H.-J. Heinze, and E. Duzel Mesolimbic Novelty Processing in Older Adults Cereb Cortex, December 1, 2007; 17(12): 2940 - 2948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Watkins, P. Dalton, N. Lavie, and G. Rees Brain Mechanisms Mediating Auditory Attentional Capture in Humans Cereb Cortex, July 1, 2007; 17(7): 1694 - 1700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Crottaz-Herbette and V. Menon Where and when the anterior cingulate cortex modulates attentional response: combined fMRI and ERP evidence. J. Cogn. Neurosci., May 1, 2006; 18(5): 766 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. J. Linden The P300: Where in the Brain Is It Produced and What Does It Tell Us? Neuroscientist, December 1, 2005; 11(6): 563 - 576. [Abstract] [PDF]
|
|
|
|
|
|
G. Yucel, C. Petty, G. McCarthy, and A. Belger Graded Visual Attention Modulates Brain Responses Evoked by Task-irrelevant Auditory Pitch Changes J. Cogn. Neurosci., December 1, 2005; 17(12): 1819 - 1828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bledowski, D. Prvulovic, K. Hoechstetter, M. Scherg, M. Wibral, R. Goebel, and D. E. J. Linden Localizing P300 Generators in Visual Target and Distractor Processing: A Combined Event-Related Potential and Functional Magnetic Resonance Imaging Study J. Neurosci., October 20, 2004; 24(42): 9353 - 9360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pins and D. ffytche The Neural Correlates of Conscious Vision Cereb Cortex, May 1, 2003; 13(5): 461 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yamasaki, K. S. LaBar, and G. McCarthy Dissociable prefrontal brain systems for attention and emotion PNAS, August 20, 2002; 99(17): 11447 - 11451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Downar, A. P. Crawley, D. J. Mikulis, and K. D. Davis A Cortical Network Sensitive to Stimulus Salience in a Neutral Behavioral Context Across Multiple Sensory Modalities J Neurophysiol, January 1, 2002; 87(1): 615 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Wible, M. Kubicki, S.-S. Yoo, D. F. Kacher, D. F. Salisbury, M. C. Anderson, M. E. Shenton, Y. Hirayasu, R. Kikinis, F. A. Jolesz, et al. A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia Am J Psychiatry, June 1, 2001; 158(6): 938 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kirino, A. Belger, P. Goldman-Rakic, and G. McCarthy Prefrontal Activation Evoked by Infrequent Target and Novel Stimuli in a Visual Target Detection Task: An Event-Related Functional Magnetic Resonance Imaging Study J. Neurosci., September 1, 2000; 20(17): 6612 - 6618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Opitz, A. Mecklinger, and A. D. Friederici Functional Asymmetry of Human Prefrontal Cortex: Encoding and Retrieval of Verbally and Nonverbally Coded Information Learn. Mem., March 1, 2000; 7(2): 85 - 96. [Abstract] [Full Text]
|
|