Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (40)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Fletcher, P.
Right arrow Articles by Dolan, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fletcher, P.
Right arrow Articles by Dolan, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol. 9, No. 2, 168-178, March 1999
© 1999 Oxford University Press

Learning-related Neuronal Responses in Prefrontal Cortex Studied with Functional Neuroimaging

Paul Fletcher1, Christian Büchel1, Oliver Josephs1, Karl Friston1 and Raymond Dolan1,2

1 The Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG and , 2 The Royal Free Hospital Medical School, Pond Street, London NW3, UK

We assessed time-dependent neuronal activity accompanying learning using functional magnetic resonance imaging (fMRI). An artificial grammar learning paradigm enabled us to dissociate activations associated with individual item learning from those involved in learning the underlying grammar system. We show that a localized region of right prefrontal cortex (PFC) is preferentially sensitive to individual item learning during the early stages of the experiment, while the left PFC region is sensitive to grammar learning which occurred across the entire course of the experiment. In addition to dissociating these two types of learning, we were able to characterize the effect of rule acquisition on neuronal responses associated with explicit learning of individual items. This effect was expressed as modulation of the time-dependent right PFC activations such that the early increase in activation associated with item learning was attenuated as the experiment progressed. In a further analysis we used structural equation modelling to explore time-dependent changes in inter-regional connectivity as a function of both item and grammar rule learning. Although there were no significant effects of item learning on the measured path strengths, rule learning was associated with a decrease in right fronto-parietal connectivity and an increase in connectivity between left and right PFC. Further fronto-parietal path strengths were observed to change, with an increase in left fronto-parietal and a decrease in right fronto-parietal connectivity. path strength from right PFC to left parietal cortex. We interpret our findings in terms of a left frontal system mediating the semantic analysis of study items and directly influencing a right fronto-parietal system associated with episodic memory retrieval.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Cogn. Neurosci.Home page
C. Ecker, M. J. Brammer, and S. C. Williams
Combining Path Analysis with Time-resolved Functional Magnetic Resonance Imaging: The Neurocognitive Network Underlying Mental Rotation.
J. Cogn. Neurosci., June 1, 2008; 20(6): 1003 - 1020.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
P. Koenig, E. E. Smith, V. Troiani, C. Anderson, P. Moore, and M. Grossman
Medial Temporal Lobe Involvement in an Implicit Memory Task: Evidence of Collaborating Implicit and Explicit Memory Systems from fMRI and Alzheimer's Disease
Cereb Cortex, April 9, 2008; (2008) bhn043v1.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
Y. Liu, M. Liang, Y. Zhou, Y. He, Y. Hao, M. Song, C. Yu, H. Liu, Z. Liu, and T. Jiang
Disrupted small-world networks in schizophrenia
Brain, April 1, 2008; 131(4): 945 - 961.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
K. I. Erickson, S. J. Colcombe, R. Wadhwa, L. Bherer, M. S. Peterson, P. E. Scalf, J. S. Kim, M. Alvarado, and A. F. Kramer
Training-Induced Functional Activation Changes in Dual-Task Processing: An fMRI Study
Cereb Cortex, January 1, 2007; 17(1): 192 - 204.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
J. L. Mueller, A. Hahne, Y. Fujii, and A. D. Friederici
Native and Nonnative Speakers' Processing of a Miniature Version of Japanese as Revealed by ERPs
J. Cogn. Neurosci., August 1, 2005; 17(8): 1229 - 1244.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
C. F. Doeller, B. Opitz, C. M. Krick, A. Mecklinger, and W. Reith
Prefrontal-hippocampal dynamics involved in learning regularities across episodes
Cereb Cortex, August 1, 2005; 15(8): 1123 - 1133.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
A. M. C. Kelly and H. Garavan
Human Functional Neuroimaging of Brain Changes Associated with Practice
Cereb Cortex, August 1, 2005; 15(8): 1089 - 1102.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J.-F. Demonet, G. Thierry, and D. Cardebat
Renewal of the Neurophysiology of Language: Functional Neuroimaging
Physiol Rev, January 1, 2005; 85(1): 49 - 95.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
M. D. Lieberman, G. Y. Chang, J. Chiao, S. Y. Bookheimer, and B. J. Knowlton
An Event-Related fMRI Study of Artificial Grammar Learning in a Balanced Chunk Strength Design
J. Cogn. Neurosci., March 1, 2004; 16(3): 427 - 438.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
P. J. Reber, D. R. Gitelman, T. B. Parrish, and M. M. Mesulam
Dissociating Explicit and Implicit Category Knowledge with fMRI
J. Cogn. Neurosci., May 1, 2003; 15(4): 574 - 583.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
P. Marangolo, C. Incoccia, L. Pizzamiglio, U. Sabatini, A. Castriota-Scanderbeg, and C. Burani
The Right Hemisphere Involvement in the Processing of Morphologically Derived Words
J. Cogn. Neurosci., April 1, 2003; 15(3): 364 - 371.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Grossman, P. Koenig, G. Glosser, C. DeVita, P. Moore, J. Rhee, J. Detre, D. Alsop, and J. Gee
Neural basis for semantic memory difficulty in Alzheimer's disease: an fMRI study
Brain, February 1, 2003; 126(2): 292 - 311.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
I. Toni, J. Rowe, K. E. Stephan, and R. E. Passingham
Changes of Cortico-striatal Effective Connectivity during Visuomotor Learning
Cereb Cortex, October 1, 2002; 12(10): 1040 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
B.A. Strange, R.N.A. Henson, K.J. Friston, and R.J. Dolan
Anterior Prefrontal Cortex Mediates Rule Learning in Humans
Cereb Cortex, November 1, 2001; 11(11): 1040 - 1046.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
E. A. Maguire, F. Vargha-Khadem, and M. Mishkin
The effects of bilateral hippocampal damage on fMRI regional activations and interactions during memory retrieval
Brain, June 1, 2001; 124(6): 1156 - 1170.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Bischoff-Grethe, S. M. Proper, H. Mao, K. A. Daniels, and G. S. Berns
Conscious and Unconscious Processing of Nonverbal Predictability in Wernicke's Area
J. Neurosci., March 1, 2000; 20(5): 1975 - 1981.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.