Cerebral Cortex, Vol 8, 730-742, Copyright © 1998 by Oxford University Press
CA Chapman, C Trepel, TL Ivanco, DJ Froc, K Wilson and RJ Racine
Repeated, daily tetanization of the corpus callosum induces lasting changes
in sensorimotor cortex field potential responses, but the synaptic
populations that mediate these responses and support long-term potentiation
(LTP) have not been characterized. Current source density analyses of field
responses were compared between control animals and those in which LTP was
induced by 10 daily series of tetanizations. Tetanization and paired-pulse
stimulation (100 ms interval) enhanced the duration of initial
(approximately 3 ms onset) deep-negative population spike activity
generated by a current sink in layer V that peaked repeatedly at a
frequency of approximately 400 Hz. The early (approximately 10 ms to peak)
surface-negative component of field responses was generated by a current
sink in upper layer V and a source in layer VI. This monosynaptic component
followed high stimulation frequencies, recovered quickly from the effects
of anaesthesia, and was enhanced by both tetanization and paired-pulse
stimulation. The late (approximately 20 ms to peak) surface-negative
component was generated by a sink in upper layer V and a source deep in
layer V, and was greatly enhanced by tetanization and paired-pulse
stimulation. The late component did not follow high-frequency stimulation
and recovered slowly from anaesthesia, suggesting that it is driven
polysynaptically. Potentiation of monosynaptic thalamic and
cortico-cortical afferents probably mediates enhancements of the early
component and population spikes, while potentiation of polysynaptic
afferents to layer V may contribute to growth in the late component.
ARTICLES
Changes in field potentials and membrane currents in rat sensorimotor cortex following repeated tetanization of the corpus callosum in vivo
Department of Psychology, McMaster University, Hamilton, Ontario, Canada.
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