Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (36)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Harding, A. J.
Right arrow Articles by Kril, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harding, A. J.
Right arrow Articles by Kril, J. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol 8, 710-718, Copyright © 1998 by Oxford University Press

ARTICLES

Variation in hippocampal neuron number with age and brain volume

AJ Harding, GM Halliday and JJ Kril
Prince of Wales Medical Research Institute, Randwick, Australia.

Hippocampal size and neuron number are reduced in a number of conditions, including temporal lobe epilepsy and Alzheimer's disease. Furthermore, a decrease with advancing age has also been suggested. The present study examined the entire hippocampal formation of 12 subjects aged from 46 to 85 years and free from neurological disease. The volume of seven subregions (CA1, CA2-3, CA4, dentate gyrus, subiculum, presubiculum and white matter) was determined and the number of neurons estimated in each of these grey matter subregions using the optical dissector technique. There was a significant relationship between CA1 neuron number and cerebrum volume. Multivariate analysis showed the greater contribution to the variance in CA1 neuron number was made by cerebrum volume (69%) rather than age (2%) or sex (1%). The findings of this study show that, in neurologically normal individuals, brain size is a major determinant of the number of CA1 neurons.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. Waydo, A. Kraskov, R. Quian Quiroga, I. Fried, and C. Koch
Sparse Representation in the Human Medial Temporal Lobe
J. Neurosci., October 4, 2006; 26(40): 10232 - 10234.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. Giannakopoulos, F. R. Herrmann, T. Bussiere, C. Bouras, E. Kovari, D. P. Perl, J. H. Morrison, G. Gold, and P. R. Hof
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
Neurology, May 13, 2003; 60(9): 1495 - 1500.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J J Kril, S Patel, A J Harding, and G M Halliday
Patients with vascular dementia due to microvascular pathology have significant hippocampal neuronal loss
J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 747 - 751.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
E. D. Bigler, N. C. Fox, R. Jenkins, and M. Rossor
Premorbid Brain Volume and Dementia
Arch Neurol, May 1, 2001; 58(5): 831 - 833.
[Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E. D. Bigler, C. M. Lowry, C. V. Anderson, S. C. Johnson, J. Terry, and M. Steed
Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype
AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1857 - 1868.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. R. Kornack and P. Rakic
Continuation of neurogenesis in the hippocampus of the adult macaque monkey
PNAS, May 11, 1999; 96(10): 5768 - 5773.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.