Cerebral Cortex, Vol 8, 602-613, Copyright © 1998 by Oxford University Press
M Levesque and A Parent
This study aimed at elucidating the branching pattern of striatal and
thalamic projections arising from prelimbic (Cg3) cortex in the rat. Small
pools (5-15 cells) of neurons were microiontophoretically injected with
biotin-dextran or biocytin and their labeled axons were individually
reconstructed from serial horizontal sections immunostained for
calbindin-D28k to delineate striatal patch/matrix compartments.
Reconstruction of > 40 axons shows that all Cg3 corticofugal fibers,
including corticothalamic axons from layer VI, course through the patch
network in the rostromedial sector of the striatum. Corticostriatal
projections arise from two types of layer V cells: (i) long-range
corticofugal neurons, whose main axons reach the brainstem and/or spinal
cord, and (ii) neurons arborizing into both striatum and claustrum, either
ipsi-, contra- or bilaterally. The axons of these two types of neurons
arborize profusely in striatal patches and only sparsely in the matrix.
Layer VI neurons do not arborize in the striatum but target principally the
thalamus. The same corticothalamic axon can innervate the anterior, rostral
intralaminar and mediodorsal thalamic nuclei. These findings support the
concept that no corticofugal fiber system exists that is solely devoted to
the striatum. They also shed new light on how neural information from
prelimbic cortex is conveyed to various subcortical limbic structures in
the rat.
ARTICLES
Axonal arborization of corticostriatal and corticothalamic fibers arising from prelimbic cortex in the rat
Laboratoire de neurobiologie, Centre de recherche Universite Laval Robert-Giffard, Beauport, Quebec, Canada.
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