Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (27)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Holcomb, H. H.
Right arrow Articles by Tamminga, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holcomb, H. H.
Right arrow Articles by Tamminga, C. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol 8, 534-542, Copyright © 1998 by Oxford University Press

Cerebral blood flow relationships associated with a difficult tone recognition task in trained normal volunteers

HH Holcomb, DR Medoff, PJ Caudill, Z Zhao, AC Lahti, RF Dannals and CA Tamminga
Maryland Psychiatric Research Center, Johns Hopkins Medical Institutes, Baltimore 21228-0247, USA. hholcomb@mprcwb.ab.umd.edu

Tone recognition is partially subserved by neural activity in the right frontal and primary auditory cortices. First we determined the brain areas associated with tone perception and recognition. This study then examined how regional cerebral blood flow (rCBF) in these and other brain regions correlates with the behavioral characteristics of a difficult tone recognition task. rCBF changes were assessed using H2(15)O positron emission tomography. Subtraction procedures were used to localize significant change regions and correlational analyses were applied to determine how response times (RT) predicted rCBF patterns. Twelve trained normal volunteers were studied in three conditions: REST, sensory motor control (SMC) and decision (DEC). The SMC-REST contrast revealed bilateral activation of primary auditory cortices, cerebellum and bilateral inferior frontal gyri. DEC-SMC produced significant clusters in the right middle and inferior frontal gyri, insula and claustrum; the anterior cingulate gyrus and supplementary motor area; the left insula/claustrum; and the left cerebellum. Correlational analyses, RT versus rCBF from DEC scans, showed a positive correlation in right inferior and middle frontal cortex; rCBF in bilateral auditory cortices and cerebellum exhibited significant negative correlations with RT These changes suggest that neural activity in the right frontal, superior temporal and cerebellar regions shifts back and forth in magnitude depending on whether tone recognition RT is relatively fast or slow, during a difficult, accurate assessment.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
K. L. Hyde, R. J. Zatorre, T. D. Griffiths, J. P. Lerch, and I. Peretz
Morphometry of the amusic brain: a two-site study
Brain, October 1, 2006; 129(10): 2562 - 2570.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Brown, M. J. Martinez, and L. M. Parsons
The Neural Basis of Human Dance
Cereb Cortex, August 1, 2006; 16(8): 1157 - 1167.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Behne, B. Wendt, H. Scheich, and A. Brechmann
Contralateral White Noise Selectively Changes Left Human Auditory Cortex Activity in a Lexical Decision Task
J Neurophysiol, April 1, 2006; 95(4): 2630 - 2637.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
C. M. Warrier and R. J. Zatorre
Right temporal cortex is critical for utilization of melodic contextual cues in a pitch constancy task
Brain, July 1, 2004; 127(7): 1616 - 1625.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Hutchinson, L. H.-L. Lee, N. Gaab, and G. Schlaug
Cerebellar Volume of Musicians
Cereb Cortex, September 1, 2003; 13(9): 943 - 949.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
A. C. Lahti, H. H. Holcomb, D. R. Medoff, M. A. Weiler, C. A. Tamminga, and W. T. Carpenter Jr.
Abnormal Patterns of Regional Cerebral Blood Flow in Schizophrenia With Primary Negative Symptoms During an Effortful Auditory Recognition Task
Am J Psychiatry, November 1, 2001; 158(11): 1797 - 1808.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Alain, S. R. Arnott, S. Hevenor, S. Graham, and C. L. Grady
""What"" and ""where"" in the human auditory system
PNAS, September 19, 2001; (2001) 211209098.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
H. H. Holcomb, A. C. Lahti, D. R. Medoff, M. Weiler, R. F. Dannals, and C. A. Tamminga
Brain Activation Patterns in Schizophrenic and Comparison Volunteers During a Matched-Performance Auditory Recognition Task
Am J Psychiatry, October 1, 2000; 157(10): 1634 - 1645.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Alain, S. R. Arnott, S. Hevenor, S. Graham, and C. L. Grady
"What" and "where" in the human auditory system
PNAS, October 9, 2001; 98(21): 12301 - 12306.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.