Cerebral Cortex, Vol 8, 462-476, Copyright © 1998 by Oxford University Press
B Ahmed, JC Anderson, RJ Douglas, KA Martin and D Whitteridge
The action potential discharge response of single neurons to both visual
stimulation and injections of current were obtained during intracellular
recordings in cat visual cortex in order to estimate the net excitatory
current arriving at the soma during visual stimulation. Of 45 neurons
recorded intracellularly, 19 pyramidal neurons and one basket cell were
labelled with horseradish peroxidase. The discharge of all neurons adapted
to constant current. For 40 neurons, a single exponential provided a good
fit to the adapting discharge (r2 = 0.73 +/- 0.03) for all current
intensities. Superficial layer neurons were significantly faster adapting
[P < 0.001, mean (+/- SEM) time constant of adaptation = 11.5 +/- 1.3
ms; n = 20] than deep layer neurons (mean time constant of adaptation =
51.4 +/- 6.4 ms; n = 10). The percentage adaptation of the spike frequency,
%(peak - adapted rate)/peak, was determined from the fitted exponential.
Superficial layer neurons adapted significantly more strongly (P < 0.01,
mean = 67 +/- 3%) than deep layer neurons (mean = 51 +/- 5%). The mean
firing frequency in response to a current step of 320 ms duration had a
linear relationship to the amplitude of the injected current (slope 66
spikes/s/nA; origin zero, mean r2 = 0.94; n = 33). This relationship
provided a means of estimating the net peak excitatory current generated by
visual stimuli. The estimated mean peak somatic current during the passage
of a bar across the receptive field was 1.1 nA and the average current for
the duration of the visually evoked discharge was 0.64 nA (n = 17). The
transfer response of real and model neurons was obtained by differentiating
the discharge response to a step input current and was then used to predict
the output of the neuron following an arbitrary input. When these transfer
responses were convolved with known input signals in model neurons, the
predicted output was close to the simulated response of the model neuron to
the same input waveforms. The transfer response was calculated for eight
real neurons. Estimates of the net excitatory current arriving at the soma
during visual stimulation was obtained by deconvolution. The mean peak
somatic current for these neurons was 0.62 nA.
ARTICLES
Estimates of the net excitatory currents evoked by visual stimulation of identified neurons in cat visual cortex
Institute of Neuroinformatics, ETH/University of Zurich, Switzerland.
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