Cerebral Cortex, Vol 8, 437-450, Copyright © 1998 by Oxford University Press
MW Jung, Y Qin, BL McNaughton and CA Barnes
Single cells were recorded with 'tetrodes' in regions of the rat medial
prefrontal cortex, including those which are targets of hippocampal
afferents, while rats were performing three different behavioral tasks: (i)
an eight-arm radial maze, spatial working memory task, (ii) a figure-eight
track, delayed spatial alternation task, and (iii) a random food search
task in a square chamber. Among 187 recorded units, very few exhibited any
evidence of place-specific firing on any of the behavioral tasks, except to
the extent that different spatial locations were related to distinct phases
of the task. Furthermore, no prefrontal unit showed unambiguous spatially
dependent delay activity that might mediate working memory for spatial
locations. Rather, the cells exhibited diverse correlates that were
generally associated with the behavioral requirements of performing the
task. This included firing related to intertrial intervals, onset or end of
trials, selection of specific arms on the eight-arm radial maze, delay
periods, approach to or departure from goals, and selection of paths on the
figure-eight track. Although a small number of cells showed similar
behavioral correlates across tasks, the majority of cells showed no
consistent correlate when recorded across multiple tasks. Furthermore, some
units did not exhibit altered firing patterns in any of the three tasks,
while others showed changes in firing that were not consistently related to
specific behaviors or task components. These results are in agreement with
previous lesion and behavioral studies in rats that suggest a prefrontal
cortical role in encoding 'rules' (i.e. structural features) or behavioral
sequences within a task but not in encoding allocentric spatial
information. Given that the hippocampal projection to this cortical region
is capable of undergoing LTP, our data lead to the hypothesis that the role
of this projection is not to impose spatial representations upon prefrontal
activity, but to provide a mechanism for learning the spatial context in
which particular behaviors are appropriate.
ARTICLES
Firing characteristics of deep layer neurons in prefrontal cortex in rats performing spatial working memory tasks
Department of Psychology, University of Arizona, Tucson 85724, USA.
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