Cerebral Cortex, Vol 8, 372-384, Copyright © 1998 by Oxford University Press
DN Kennedy, N Lange, N Makris, J Bates, J Meyer and VS Caviness Jr
This magnetic resonance imaging (MRI)-based morphometric analysis of
cortical topography in the human brain is based upon the segmentation and
parcellation of volumetric T1-weighted MRI data for a set of 20 young adult
brains including 10 males and 10 females. For the most part, each
parcellation unit (PU) of the neocortex corresponds to a single or a
portion of a single gyrus. The volumes of each PU were computed for each
brain. Subsets of PUs were also grouped so as to represent the neocortex
for the frontal, temporal, parietal and occipital lobes. The coefficient of
variation of the mean volume of total neocortex and that of the neocortex
assigned to individual lobes cluster around 10%, whereas that of neocortex
assigned to the individual gyri (PU) is more than twice that value.
Approximately 80% of the total variance in gyral volume arises from
determinants interactive for individual and specific gyri, while only
approximately 10% of the total variance appears to be a reflection of
uniform scaling to total neocortical volume. Sexual dimorphism contributes
a pervasive though relatively small component of this variance. These
results have implications for the study of structure-function correlation,
and the proper statistical methods of handling volumetric data in
morphometric studies. In addition, the nature of the covariance structure
of the data will lead to future hypotheses regarding the relationships
between the various potential genetic and epigenetic gyral influencing
factors.
ARTICLES
Gyri of the human neocortex: an MRI-based analysis of volume and variance
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA. dave@cma.mgh.harvard.edu
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