Cerebral Cortex, Vol 8, 269-277, Copyright © 1998 by Oxford University Press
C Aoki, C Venkatesan, CG Go, R Forman and H Kurose
A series of electron microscopic immunocytochemical studies was performed
to analyze subcellular sites for noradrenergic modulation in monkey
prefrontal cortex. One out of 12 noradrenergic varicosities, identified by
dopamine beta-hydroxylase immunocytochemistry within single ultrathin
sections, forms morphologically identifiable junctions with small dendrites
and spines. Accordingly, alpha2-adrenergic receptors, almost all of which
are of the A-subtype, that occur in spines are localized discretely over
postsynaptic membranes. alpha2- Adrenergic receptors are also found at
sites along axons, dendritic shafts and astrocytic processes lacking
morphologically identifiable synaptic junctions, suggesting that these
receptors are activated by volume transmission. In particular, axonal
alpha2-adrenergic receptors occur mostly at pre-terminal regions,
suggesting that axo-axonic interactions may mediate reduction of
neurotransmitter release at sites other than axo-spinous junctions by
closing voltage-dependent calcium channels. These results indicate that
noradrenergic modulation of prefrontal cortex involves synaptic
interactions at spines of pyramidal neurons and nonsynaptic volume
transmission to glia, dendritic shafts and axons.
ARTICLES
Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization of noradrenergic receptors and axons
Center for Neural Science, New York University, NY 10003, USA. chiye@cns.nyu.edu
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