Cerebral Cortex, Vol 8, 218-226, Copyright © 1998 by Oxford University Press
M Luciana, PF Collins and RA Depue
Neurocognitive research has focused on monoaminergic influences over broad
behavior patterns. For example, dopamine (DA) generally facilitates
informational transfer within limbic and cortical networks to promote
reward-seeking behavior. Specifically, DA activity in prefrontal cortex
modulates the ability for nonhuman primates and humans to perform spatial
working memory tasks. Serotonin (5HT) constrains the activity of DA,
resulting in an opposing relationship between DA and 5HT with respect to
emotional and motor behaviors. A role for 5HT in constraining prefrontally
guided spatial working memory (WM) processes in humans has not been
empirically demonstrated but is a logical avenue for study if these
principles of neurotransmitter activity hold within cortical networks. In
this study, normal humans completed a visuospatial WM task under
pharmacological challenge with (i) bromocriptine, a DA agonist and (ii)
fenfluramine, a serotonin agonist, in a double-blind, repeated-measures,
placebo-controlled design. Findings indicate that bromocriptine facilitated
spatial delayed, but not immediate, memory performance. Fenfluramine
resulted in impaired delayed spatial memory. These effects were not due to
nonspecific arousal, attentional, sensorimotor or perceptual changes. These
findings suggest that monoaminergic neurotransmitters (DA and 5HT) may
interact within cortical networks to modulate the expression of specific
cognitive behaviors, particularly effortful processes associated with
goal-directed activity.
ARTICLES
Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions
Department of Psychology, University of Oregon, Eugene, USA. lucia003@maroon.tc.umn.edu
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