Cerebral Cortex, Vol 8, 80-96, Copyright © 1998 by Oxford University Press
YC Okada and S Salenius
Neuronal activity of the human brain was studied with
magnetoencephalography (MEG) in a spatial working memory task similar to
those commonly used with nonhuman primates. The subject was required to
remember target positions for 3 s and make a same-different judgement with
a finger lift comparing the position of the probed target with the probe or
to execute a memory-guided saccade to the probed target. In this type of
task single-unit studies have shown attention- and memory-related
activities independent of movement type during the retention interval in a
large number of cortical areas of the primates, including the parietal and
prefrontal areas. Consistent with these results, there were strong
stimulus-driven transient and sustained responses and modulations of
oscillatory activity during the retention period. Although we did not
determine the source locations, coarse estimates of the currents
responsible for the MEG signals showed activity over a wide area of the
cortex, most prominently over the Rolandic, parietal and occipital areas,
but also over the frontal area. Some of the activities in these cortical
areas reflect processes that may be identified with attention and memory,
while others were related to preparation of the overt movements.
ARTICLES
Roles of attention, memory, and motor preparation in modulating human brain activity in a spatial working memory task
Department of Neurology, University of New Mexico School of Medicine, Albuquerque 87131, USA.
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