Cerebral Cortex, Vol 8, 63-72, Copyright © 1998 by Oxford University Press
XO Zhu and PM Waite
This experiment examines the impact of the cholinergic input from the basal
forebrain on the plasticity of the vibrissa-related somatosensory cortex.
Newborn rat pups received intraventricular injections of the cholinergic
immunotoxin IgG192-saporin, after bilateral removal of the C-line whisker
follicles. Compared with saline-injected control animals, unilateral
injections of 0.1 microg IgG192-saporin decreased the number of cholinergic
neurons on the toxin injected side by 78% in the basal nucleus of Meynert
and the vertical limb of the diagonal band of Broca, 80% in the
magnocellular preoptic nucleus and the horizontal limb of the diagonal band
of Broca, and 54% in the medial septal nucleus. Neuronal loss contralateral
to the toxin was approximately half that on the ipsilateral side. The size
of the C and D row barrels were compared from tangential sections through
the barrel field. In control animals, D row barrels expanded into C row
territory, giving a ratio of areas for D/C barrels of 2.03. Depletion of
the cholinergic neurons reduced the expansion of D row barrels and hence
decreased the D/C ratio, with a greater reduction on the toxin-treated side
(1.43, P <0.005) compared with the contralateral side (1.64, P
<0.05). This study implicates the basal forebrain cholinergic projection
in somatosensory cortical plasticity.
ARTICLES
Cholinergic depletion reduces plasticity of barrel field cortex
School of Anatomy, University of New South Wales, Sydney, Australia.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Takasaki, R. Okada, A. Mitani, M. Fukaya, M. Yamasaki, Y. Fujihara, T. Shirakawa, K. Tanaka, and M. Watanabe Glutamate Transporters Regulate Lesion-Induced Plasticity in the Developing Somatosensory Cortex J. Neurosci., May 7, 2008; 28(19): 4995 - 5006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. L. Hanganu, J. F. Staiger, Y. Ben-Ari, and R. Khazipov Cholinergic Modulation of Spindle Bursts in the Neonatal Rat Visual Cortex In Vivo J. Neurosci., May 23, 2007; 27(21): 5694 - 5705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Choi, J. Chang, B. Jiang, G.-H. Seol, S.-S. Min, J.-S. Han, H.-S. Shin, M. Gallagher, and A. Kirkwood Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex J. Neurosci., December 7, 2005; 25(49): 11433 - 11443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Prakash, S. Cohen-Cory, S. Penschuck, and R. D. Frostig Basal Forebrain Cholinergic System Is Involved in Rapid Nerve Growth Factor (NGF)-Induced Plasticity in the Barrel Cortex of Adult Rats J Neurophysiol, January 1, 2004; 91(1): 424 - 437. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Mesulam The Cholinergic Lesion of Alzheimer's Disease: Pivotal Factor or Side Show? Learn. Mem., January 1, 2004; 11(1): 43 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bao, V. T. Chan, L. I. Zhang, and M. M. Merzenich Suppression of cortical representation through backward conditioning PNAS, February 4, 2003; 100(3): 1405 - 1408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Kilgard, P. K. Pandya, J. Vazquez, A. Gehi, C. E. Schreiner, and M. M. Merzenich Sensory Input Directs Spatial and Temporal Plasticity in Primary Auditory Cortex J Neurophysiol, July 1, 2001; 86(1): 326 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kirkwood, C. Rozas, J. Kirkwood, F. Perez, and M. F. Bear Modulation of Long-Term Synaptic Depression in Visual Cortex by Acetylcholine and Norepinephrine J. Neurosci., March 1, 1999; 19(5): 1599 - 1609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. B. Aramakis and R. Metherate Nicotine Selectively Enhances NMDA Receptor-Mediated Synaptic Transmission during Postnatal Development in Sensory Neocortex J. Neurosci., October 15, 1998; 18(20): 8485 - 8495. [Abstract] [Full Text] [PDF]
|
|