Cerebral Cortex, Vol 7, 711-721, Copyright © 1997 by Oxford University Press
F Wang, C Bergson, RL Howard and MS Lidow
Previous film autoradiographic studies demonstrated that, during
corticogenesis, dopamine receptors of the D1 class are abundant in the
embryonic primate cerebral wall. In the present study, we expand these
findings by identifying the cellular elements of the fetal occipital
cerebral wall expressing D1 and D5 subtypes of the D1 dopamine receptor
class. We have examined tissue from monkey fetuses collected at 70, 90 and
120 days of gestation using antibodies directed against C-termini of the D1
and D5 dopamine receptors. At all three embryonic ages studied, we found D1
and D5 receptors expressed by multiple cell types of the embryonic cerebral
wall. Both D1 and D5 receptor proteins are produced by pyramidal neurons of
the cortical plate and by a variety of interstitial neurons of the subplate
and intermediate zones. D1 and D5 receptors are also present in cells of
the proliferative ventricular and subventricular zones, some of which were
identified as dividing cells. In addition, D1 and D5 receptors are
detectable in the protoplasmic astroglial and ependymal cells
distinguishable in monkey fetuses collected at 120 days of gestation. Some
cellular elements of the embryonic monkey cerebral wall express only one
subtype of the D1 dopamine receptor class. For example, embryonic
Cajal-Retzius neurons in the marginal zone and migrating neurons in the
intermediate zone are immunoreactive only to D5 antisera. In contrast,
radial glia can be labeled only with D1 receptor-specific antisera.
Finally, only D1 receptors are detectable in the blood vessels penetrating
the embryonic monkey cerebral wall. Based on these observations, we propose
that dopamine receptors of the D1 class play an important role in
regulating cerebral cortical formation and that D1 and D5 receptor subtypes
may participate in regulation of different aspects of this process.
ARTICLES
Differential expression of D1 and D5 dopamine receptors in the fetal primate cerebral wall
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
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