Cerebral Cortex, Vol 7, 678-689, Copyright © 1997 by Oxford University Press
S Miyama, T Takahashi, RS Nowakowski and VS Caviness Jr
Neuronogenesis in the neocortical pseudostratified ventricular epithelium
(PVE) is initiated rostrolaterally and progresses caudo- medially as
development progresses. Here we have measured the cytokinetic parameters
and the fractional neuronal output parameter, Q, of laterally located
early-maturing regions over the principal embryonic days (E12-E15) of
neocortical neuronogenesis in the mouse. These measures are compared with
ones previously made of a medial, late- maturing portion of the PVE.
Laterally, as medially, the duration of the neuronogenetic interval is 6
days and comprises 11 integer cell cycles. Also, in both lateral and medial
areas the length of G1 phase (TG1) increases nearly 4-fold and is the only
cell cycle parameter to change. Q progresses essentially identically
laterally and medially with respect to the succession of integer cell
cycles. Most importantly, from E12 to E13 there is a steeply declining
lateral to medial gradient in TG1. The gradient is due both to the lateral
to medial graded stage of neuronogenesis and to the stepwise increase in
TG1 with each integer cycle during the neuronogenetic interval. To our
knowledge this gradient in TG1 of the cerebral PVE is the first cell
biological gradient to be demonstrated experimentally in such an extensive
proliferative epithelial sheet. We suggest that this gradient in TG1 is the
cellular mechanism for positionally encoding a protomap of the neocortex
within the PVE.
ARTICLES
A gradient in the duration of the G1 phase in the murine neocortical proliferative epithelium
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Friocourt, S. Kanatani, H. Tabata, M. Yozu, T. Takahashi, M. Antypa, O. Raguenes, J. Chelly, C. Ferec, K. Nakajima, et al. Cell-Autonomous Roles of ARX in Cell Proliferation and Neuronal Migration during Corticogenesis J. Neurosci., May 28, 2008; 28(22): 5794 - 5805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Suter, R. S. Nowakowski, P. G. Bhide, and V. S. Caviness Navigating Neocortical Neurogenesis and Neuronal Specification: A Positional Information System Encoded by Neurogenetic Gradients J. Neurosci., October 3, 2007; 27(40): 10777 - 10784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Gohlke, W. C. Griffith, and E. M. Faustman Computational Models of Neocortical Neuronogenesis and Programmed Cell Death in the Developing Mouse, Monkey, and Human Cereb Cortex, October 1, 2007; 17(10): 2433 - 2442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fukumitsu, M. Ohtsuka, R. Murai, H. Nakamura, K. Itoh, and S. Furukawa Brain-Derived Neurotrophic Factor Participates in Determination of Neuronal Laminar Fate in the Developing Mouse Cerebral Cortex J. Neurosci., December 20, 2006; 26(51): 13218 - 13230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Woodhead, C. A. Mutch, E. C. Olson, and A. Chenn Cell-Autonomous beta-Catenin Signaling Regulates Cortical Precursor Proliferation J. Neurosci., November 29, 2006; 26(48): 12620 - 12630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tarui, T. Takahashi, R.S. Nowakowski, N.L. Hayes, P.G. Bhide, and V.S. Caviness Overexpression of p27Kip1, Probability of Cell Cycle Exit, and Laminar Destination of Neocortical Neurons Cereb Cortex, September 1, 2005; 15(9): 1343 - 1355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Gohlke, W. C. Griffith, and E. M. Faustman A Systems-Based Computational Model for Dose-Response Comparisons of Two Mode of Action Hypotheses for Ethanol-Induced Neurodevelopmental Toxicity Toxicol. Sci., August 1, 2005; 86(2): 470 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zimmer, M.-C. Tiveron, R. Bodmer, and H. Cremer Dynamics of Cux2 Expression Suggests that an Early Pool of SVZ Precursors is Fated to Become Upper Cortical Layer Neurons Cereb Cortex, December 1, 2004; 14(12): 1408 - 1420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Hodge, A. J. D'Ercole, and J. R. O'Kusky Insulin-Like Growth Factor-I Accelerates the Cell Cycle by Decreasing G1 Phase Length and Increases Cell Cycle Reentry in the Embryonic Cerebral Cortex J. Neurosci., November 10, 2004; 24(45): 10201 - 10210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Roy, K. Kuznicki, Q. Wu, Z. Sun, D. Bock, G. Schutz, N. Vranich, and A. P. Monaghan The Tlx Gene Regulates the Timing of Neurogenesis in the Cortex J. Neurosci., September 22, 2004; 24(38): 8333 - 8345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bellion, M. Wassef, and C. Metin Early Differences in Axonal Outgrowth, Cell Migration and GABAergic Differentiation Properties between the Dorsal and Lateral Cortex Cereb Cortex, February 1, 2003; 13(2): 203 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, S. Andersson, M. Warner, and J.-A. Gustafsson Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain PNAS, January 21, 2003; 100(2): 703 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Cunningham and M. F. Roussel Cyclin-dependent Kinase Inhibitors in the Development of the Central Nervous System Cell Growth Differ., August 1, 2001; 12(8): 387 - 396. [Full Text] [PDF]
|
|
|
|
|
|
T. Mitsuhashi, Y. Aoki, Y. Z. Eksioglu, T. Takahashi, P. G. Bhide, S. A. Reeves, and V. S. Caviness Jr. Overexpression of p27Kip1 lengthens the G1 phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells PNAS, May 22, 2001; 98(11): 6435 - 6440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dehay, P. Savatier, V. Cortay, and H. Kennedy Cell-Cycle Kinetics of Neocortical Precursors Are Influenced by Embryonic Thalamic Axons J. Neurosci., January 1, 2001; 21(1): 201 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Raballo, J. Rhee, R. Lyn-Cook, J. F. Leckman, M. L. Schwartz, and F. M. Vaccarino Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex J. Neurosci., July 1, 2000; 20(13): 5012 - 5023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Soria and A. Fairen Cellular Mosaics in the Rat Marginal Zone Define an Early Neocortical Territorialization Cereb Cortex, April 1, 2000; 10(4): 400 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Delalle, T. Takahashi, R.S. Nowakowski, L.-H. Tsai, and V.S. Caviness Jr Cyclin E-p27 Opposition and Regulation of the G1 Phase of the Cell Cycle in the Murine Neocortical PVE: A Quantitative Analysis of mRNA In Situ Hybridization Cereb Cortex, December 1, 1999; 9(8): 824 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takahashi, T. Goto, S. Miyama, R. S. Nowakowski, and V. S. Caviness Jr Sequence of Neuron Origin and Neocortical Laminar Fate: Relation to Cell Cycle of Origin in the Developing Murine Cerebral Wall J. Neurosci., December 1, 1999; 19(23): 10357 - 10371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Takahashi, R.S. Nowakowski, and V.S. Caviness Jr Review : Cell Cycle as Operational Unit of Neocortical Neuronogenesis Neuroscientist, May 1, 1999; 5(3): 155 - 163. [Abstract] [PDF]
|
|