Cerebral Cortex, Vol 7, 559-570, Copyright © 1997 by Oxford University Press
B Ahmed, JD Allison, RJ Douglas and KA Martin
Extracellular recordings indicate that mechanisms that control contrast
gain of neuronal discharge are found in the retina, thalamus and cortex. In
addition, the cortex is able to adapt its contrast response function to
match the average local contrast. Here we examine the neuronal mechanism of
contrast adaptation by direct intracellular recordings in vivo. Both simple
(n = 3) and complex cells (n = 4) show contrast adaptation during
intracellular recording. For simple cells, that the amplitude of
fluctuations in membrane potential induced by a drifting grating stimulus
follows a contrast response relation similar to lateral geniculate relay
cells, and does not reflect the high gain and adaptive properties seen in
the action potential discharge of the neurons. We found no evidence of
significant shunting inhibition that could explain these results. In
complex cells there was no change in the mean membrane potential for
different contrast stimuli or different states of adaptation, despite
marked changes in discharge rate. We use a simplified electronic model to
discuss the central features of our results and to explain the disparity
between the contrast response functions of the membrane potential and
action potential discharge in simple cells.
ARTICLES
An intracellular study of the contrast-dependence of neuronal activity in cat visual cortex
Institute of Neuroinformatics, ETH/UNIZ, Zurich, Switzerland.
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