Cerebral Cortex, Vol 7, 534-545, Copyright © 1997 by Oxford University Press
R Azouz, CM Gray, LG Nowak and DA McCormick
Physiological and morphological properties of identified interneurons in
the striate cortex of the cat were studied in vivo by intracellular
recording and staining with biocytin. In conformity with in vitro studies,
these non-pyramidal fast spiking cells have very brief action potentials
associated with a high rate of fall, and a large hyperpolarizing
afterpotential. These cells show high discharge rates, little or no spike
frequency adaptation in response to depolarizing current injection, as well
as a diverse range of firing patterns. Three of the cells were labeled and
were found to be aspiny or sparsely spiny basket cells, with bitufted or
radial dendritic arrangements, in layers II-IV. Their axonal arborizations
were more dense near their somata and extended horizontally or vertically.
Of 13 visually responsive cells tested, the receptive field properties of
six cells and the orientation and direction preferences of eight cells were
determined. Five of the successfully mapped cells had simple receptive
fields while one had a complex receptive field type. The orientation and
direction tuning properties of the overlapping set of eight cells showed a
broad spectrum ranging from unselective to tightly tuned. The majority
exhibited a clear preference for orientation and none of the cells were
clearly direction selective. Quantitative analysis of the temporal
properties of the spike trains during visual stimulation and spontaneous
activity revealed that these cells do not exhibit any significant periodic
activity, and fired at rates that were well below their maximum in response
to depolarizing current pulses.
ARTICLES
Physiological properties of inhibitory interneurons in cat striate cortex
Center for Neuroscience, University of California, Davis 95616, USA. rony@chaos.ucdavis.edu
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