Cerebral Cortex, Vol 7, 268-282, Copyright © 1997 by Oxford University Press
N Raz, FM Gunning, D Head, JH Dupuis, J McQuain, SD Briggs, WJ Loken, AE Thornton and JD Acker
In a prospective cross-sectional study, we used computerized volumetry of
magnetic resonance images to examine the patterns of brain aging in 148
healthy volunteers. The most substantial age-related decline was found in
the volume of the prefrontal gray matter. Smaller age-related differences
were observed in the volume of the fusiform, inferior temporal and superior
parietal cortices. The effects of age on the hippocampal formation, the
postcentral gyrus, prefrontal white matter and superior parietal white
matter were even weaker. No significant age- related differences were
observed in the parahippocampal and anterior cingulate gyri, inferior
parietal lobule, pericalcarine gray matter, the precentral gray and white
matter, postcentral white matter and inferior parietal white matter. The
volume of the total brain volume and the hippocampal formation was larger
in men than in women even after adjustment for height. Inferior temporal
cortex showed steeper aging trend in men. Small but consistent rightward
asymmetry was found in the whole cerebral hemispheres, superior parietal,
fusiform and orbito-frontal cortices, postcentral and prefrontal white
matter. The left side was larger than the right in the dorsolateral
prefrontal, parahippocampal, inferior parietal and pericalcarine cortices,
and in the parietal white matter. However, there were no significant
differences in age trends between the hemispheres.
ARTICLES
Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter
Department of Psychology, University of Memphis, TN 38152, USA.
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