Cerebral Cortex, Vol 7, 157-165, Copyright © 1997 by Oxford University Press
JL Armony, D Servan-Schreiber, LM Romanski, JD Cohen and JE LeDoux
The conditioning of fear responses to a simple acoustic stimulus (pure
tone) paired with footshock can be mediated by the transmission of auditory
information to the lateral nucleus of the amygdala from either the auditory
thalamus or the auditory cortex. We examined the processing capacity of the
thalamo-amygdala pathway by making lesions of the auditory cortex and
testing the extent to which conditioned fear responses generalized to tones
other than the one paired with footshock. Two studies were performed, one
in an anatomically constrained computational model of the fear conditioning
network and the other in rats. Stimulus generalization was unaffected in
both. These findings support the validity of the model as an approach to
studying the neural basis of conditioned fear learning, and in addition
suggest that the thalamo-amygdala pathway, possibly by the use of
population coding, is capable of performing at least crude stimulus
discriminations.
ARTICLES
Stimulus generalization of fear responses: effects of auditory cortex lesions in a computational model and in rats
Center for Neural Science, New York University, New York, NY 10003, USA.
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