Cerebral Cortex, Vol 7, 130-142, Copyright © 1997 by Oxford University Press
GS Schierle, JC Gander, C D'Orlando, MR Ceilo and DM Vogt Weisenhorn
Postnatal development of the rat cortex is characterized by the gradual
development of many calcium-dependent processes which demand a precise
control of the intracellular levels of this cation; when the balance is
disturbed, neuronal death ultimately ensues. Calretinin (CR), a calcium-
binding protein, has been postulated to have neuroprotective capacity by
buffering intracellular calcium. This putative relationship between CR and
neuroprotection is still, however, a controversial issue. With a view to
shedding further light on this subject, we studied the temporal and spatial
distribution of CR in five different regions (the frontal- sensorimotor-,
parietal-, temporal- and occipital region) of the rat cortex during
postnatal development. Qualitative and quantitative immunocytochemistry of
newborn, 5-, 10-, 15-, 20- and 30-day-old and adult rats revealed a
profound increase in the density of the CR- positive neurons during the
first two postnatal weeks in all regions examined. At the end of this
period, CR-immunoreactive cells decreased sharply to adult levels. Cell
classes exhibiting transient CR- immunoreactivity during the first two
postnatal weeks included cells in layer I (amongst which were Cajal-Retzius
cells), the subplate and pyramidal-like cells in the upper portion of layer
V, most of them in the motor cortices. The above-described dynamics of CR
expression were reflected also in the biochemical analysis performed
(immunoblotting, ELISA). The temporal and spatial correlation with
calcium-dependent events such as synaptogenesis, neurite elongation and
remodelling in further support the contention that CR may play a
neuroprotective role during postnatal development of the rat cortex.
ARTICLES
Calretinin-immunoreactivity during postnatal development of the rat isocortex: a qualitative and quantitative study
Institute of Histology and General Embryology, University of Fribourg, Switzerland.
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