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Cerebral Cortex 1996; 6:823-829
© Oxford University Press 1996

The Parahippocampus Subserves Topographical Learning in Man

Geoffrey K. Aguirre1, John A. Detre1,2, David C. Alsop2 and Mark D'Esposito1

1 Departments of Neurology, University of Pennsylvania Philadelphia, PA 19104, USA, 2 Departments of Radiology, University of Pennsylvania Philadelphia, PA 19104, USA

Address correspondence to Mark D'Esposito, MD, Cognitive Neurology Section, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA

The hippocampus has been proposed as the site of neural representation of large-scale environmental space, based upon the identification of place cells (neurons with receptive fields for current position in the environment) within the rat hippocampus and the demonstration that hippocampal lesions impair place learning in therat. The inability to identify place cells within the monkey hippocampus and the observation that unilateral hippocampal lesions do not selectively impair topographic behavior in humans suggest that alternate regions may subserve this function in man. To examine the contribution of the hippocampus and adjacent medial-temporal lobe structures to topographic learning in the human, a ‘virtual’ maze was used as a task environment during functional magnetic resonance imaging studies. During the learning and recall of topographic information, medial-temporal activity was confined to the para- hippocampal gyri. This activity accords well with the lesion site known to produce topographical disorientation in humans. Activity was also observed in cortical areas known to project to the parahippocampus and previously proposed to contribute to a network subserving spatially guided behavior.


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