Cerebral Cortex 1996; 6:311-318
© Oxford University Press 1996
research-article |
Prefrontal Cortex and Working Memory for Spatial Response, Spatial Location, and Visual Object Information in the Rat
Department of Psychology, University of Utah Salt Lake City Utah 84112
Address correspondence to Raymond P. Kesner, Department of Psychology, University of Utah, Salt Lake City, UT 84112
In the first experiment, rats were trained on a working memory task for a spatial response (right-left turn) information using a delayed matching-to-sample procedure. Following lesions of the medial prefrontal cortex (MPF), which includes anterior cingulate and medial precentral cortex, there was a profound working memory deficit even at the shortest delay. In the second experiment, rats were trained on a working memory task for spatial location information using a delayed matching-to-sample procedure. Following lesions of the MPF, there was only a mild working memory deficit, whereas following dorsal hippocampal lesions there was a profound working memory deficit even at the shortest delay. In the third experiment, rats were trained on a working memory task for visual object information using a delayed nonmatching-to-sample procedure. Following lesions of the MPF, there were no working memory deficits, whereas following lesions of the prelimbic and infralimbic cortex there was a profound working memory deficit even at the shortest delay. The results suggest that different neural subregions of the prefrontal cortex mediate working memory for specific attribute information.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. B. Moraes Resstel, F. M. de Aguiar Correa, and F. S. Guimaraes The Expression of Contextual Fear Conditioning Involves Activation of an NMDA Receptor-Nitric Oxide Pathway in the Medial Prefrontal Cortex Cereb Cortex, September 1, 2008; 18(9): 2027 - 2035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoon, J. Okada, M. W. Jung, and J. J. Kim Prefrontal cortex and hippocampus subserve different components of working memory in rats Learn. Mem., February 19, 2008; 15(3): 97 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. FURUYASHIKI and M. GALLAGHER Neural Encoding in the Orbitofrontal Cortex Related to Goal-Directed Behavior , December 1, 2007; 1121(1): 193 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Kargo, B. Szatmary, and D. A. Nitz Adaptation of Prefrontal Cortical Firing Patterns and Their Fidelity to Changes in Action-Reward Contingencies J. Neurosci., March 28, 2007; 27(13): 3548 - 3559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. I. Barker, F. Bird, V. Alexander, and E. C. Warburton Recognition Memory for Objects, Place, and Temporal Order: A Disconnection Analysis of the Role of the Medial Prefrontal Cortex and Perirhinal Cortex J. Neurosci., March 14, 2007; 27(11): 2948 - 2957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Mitchell and J. C. Dalrymple-Alford Lateral and anterior thalamic lesions impair independent memory systems. Learn. Mem., May 1, 2006; 13(3): 388 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.R. Bailey and R.G. Mair Dissociable Effects of Frontal Cortical Lesions on Measures of Visuospatial Attention and Spatial Working Memory in the Rat Cereb Cortex, September 1, 2004; 14(9): 974 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Hannesson, J. G. Howland, and A. G. Phillips Interaction between Perirhinal and Medial Prefrontal Cortex Is Required for Temporal Order But Not Recognition Memory for Objects in Rats J. Neurosci., May 12, 2004; 24(19): 4596 - 4604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ishikawa and S. Nakamura Convergence and Interaction of Hippocampal and Amygdalar Projections within the Prefrontal Cortex in the Rat J. Neurosci., November 5, 2003; 23(31): 9987 - 9995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. I. O. Myme, K. Sugino, G. G. Turrigiano, and S. B. Nelson The NMDA-to-AMPA Ratio at Synapses Onto Layer 2/3 Pyramidal Neurons Is Conserved Across Prefrontal and Visual Cortices J Neurophysiol, August 1, 2003; 90(2): 771 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.F. Kritzer Long-term Gonadectomy Affects the Density of Tyrosine Hydroxylase- but not Dopamine-{beta}-hydroxylase-, Choline Acetyltransferase- or Serotonin-immunoreactive Axons in the Medial Prefrontal Cortices of Adult Male Rats Cereb Cortex, March 1, 2003; 13(3): 282 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Passetti, Y. Chudasama, and T. W. Robbins The Frontal Cortex of the Rat and Visual Attentional Performance: Dissociable Functions of Distinct Medial Prefrontal Subregions Cereb Cortex, December 1, 2002; 12(12): 1254 - 1268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Ragozzino The Effects of Dopamine D1 Receptor Blockade in the Prelimbic-Infralimbic Areas on Behavioral Flexibility Learn. Mem., January 1, 2002; 9(1): 18 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Kesner, A. Ravindranathan, P. Jackson, R. Giles, and A. A. Chiba A Neural Circuit Analysis of Visual Recognition Memory: Role of Perirhinal, Medial, and Lateral Entorhinal Cortex Learn. Mem., March 1, 2001; 8(2): 87 - 95. [Abstract] [Full Text]
|
|
|
|
|
|
M. E. Ragozzino, S. Detrick, and R. P. Kesner Involvement of the Prelimbic-Infralimbic Areas of the Rodent Prefrontal Cortex in Behavioral Flexibility for Place and Response Learning J. Neurosci., June 1, 1999; 19(11): 4585 - 4594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Durstewitz, M. Kelc, and O. Gunturkun A Neurocomputational Theory of the Dopaminergic Modulation of Working Memory Functions J. Neurosci., April 1, 1999; 19(7): 2807 - 2822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. H. Miner, M. Ostrander, and M. Sarter Effects of ibotenic acid-induced loss of neurons in the medial prefrontal cortex of rats on behavioral vigilance: evidence for executive dysfunction J Psychopharmacol, January 1, 1997; 11(2): 169 - 178. [Abstract] [PDF]
|
|