Cerebral Cortex 1995; 5:391-409
© Oxford University Press 1995
research-article |
Representing Spatial Information for Limb Movement: Role of Area 5 in the Monkey
1Istituto di Fisiologia umana, Università di Cagliari Cagliari, 2INB-CNR, Istituto Scientifico S. Lucia Rome, 3Istituto di Fisiologia umana, Università La Sapienza, Rome Italy
Address correspondence to Prof. F. Lacquaniti, Sez. Ricerche Fisiologlaumana, CNR, Istituto Sclentlfico S. Lucia, via Ardeatina 306, 00179 Roma (Italy).
How is spatial information for limb movement encoded in the brain? Computational and psychophysical studies suggest that beginning hand position, via-points, and target are specified relative to the body to afford a comparison between the sensory (e. g., kinesthetic) reaf-ferences and the commands that generate limb movement Here we propose that the superior parietal lobule (Brodmann area 5) might represent a substrata for a body-centered positional code. Monkeys made arm movements in different parts of 3D space in a reaction-time task. We found that the activity of area 5 neurons can be related to either the starting point or the final point or combinations of the two. Neural activity is monotonicalty tuned in a body-centered frame of reference, whose coordinates define the azimuth, elevation, and distance of the hand. Each spatial coordinate tends to be encoded in a different sub-population of neurons. This parcellation could be a neural correlate of the psychophysical observation that these spatial parameters are processed in parallel and largely independent of each other in man.
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|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 M. Iacoboni, R. P. Woods, M. Brass, H. Bekkering, J. C. Mazziotta, and G. Rizzolatti Cortical Mechanisms of Human Imitation Science, December 24, 1999; 286(5449): 2526 - 2528. [Abstract] [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
M.F.S. Rushworth, H. Johansen-Berg, and S. A. Young Parietal Cortex and Spatial-Postural Transformation During Arm Movements J Neurophysiol, January 1, 1998; 79(1): 478 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Scott, L. E. Sergio, and J. F. Kalaska Reaching Movements With Similar Hand Paths but Different Arm Orientations. II. Activity of Individual Cells in Dorsal Premotor Cortex and Parietal Area 5 J Neurophysiol, November 1, 1997; 78(5): 2413 - 2426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-G. Fu, D. Flament, J. D. Coltz, and T. J. Ebner Relationship of Cerebellar Purkinje Cell Simple Spike Discharge to Movement Kinematics in the Monkey J Neurophysiol, July 1, 1997; 78(1): 478 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Buneo, J. F. Soechting, and M. Flanders Postural Dependence of Muscle Actions: Implications for Neural Control J. Neurosci., March 15, 1997; 17(6): 2128 - 2142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Scott and J. F. Kalaska Reaching Movements With Similar Hand Paths But Different Arm Orientations. I. Activity of Individual Cells in Motor Cortex J Neurophysiol, February 1, 1997; 77(2): 826 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J L Contreras-Vidal, S Grossberg, and D Bullock A neural model of cerebellar learning for arm movement control: cortico-spino-cerebellar dynamics. Learn. Mem., January 1, 1997; 3(6): 475 - 502. [Abstract] [PDF]
|
|