Cerebral Cortex 1993; 3:515-532
© Oxford University Press 1993
research-article |
Information Cascade from Primary Auditory Cortex to the Amygdala: Corticocortical and Corticoamygdaloid Projections of Temporal Cortex in the Rat
Center for Neural Science, New York University New York, New York 10003
Corticocortical and corticoamygdaloid connections of temporal cortext and perirhinal cortex (PRh) were examined in the rat with the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHA-L). lontophoretic injections of PHA-L into area TE1 resulted in columnar axonal terminations in surrounding and contralateral regions of temporal neocortex and in the striatum, but not in the amygdala. Within temporal neocortex, labeled fibers were present locally in adjacent regions of TE1, as well as in TE2d, TE1v, TE3v, and TE2c. Injection of cortical areas TE1v, TE3v, and TE2c, which received projections from TE1, or injections of perirhinal periallocortex, which received projections from TE1v, TE2v, and TE3v, resulted in projections to the amygdala. The pattern of corticocortical and corticoamygdaloid projections differed among the divisions of auditory cortex. TE1 exhibited extensive ipsilateral and contralateral projections to temporal cortical regions and no projections to the amygdala. In contrast, areas of temporal neocortex ventral and posterior to TE1, including TE1v, TE3v, TE2c, and PRh, had more limited ipsi- and contralateral corticocortical projections but had an increased connectivity with the subcortical forebrain, especially the lateral nucleus of the amygdala (AL). There was a topographic organization to the AL afferents. The dorsal subdivision of AL received projections from TE1v, TE3v, TE2c, and PRh, while the ventrolateral division received projections from TE3v, TE2c, and PRh. The ventromedial division received projections only from PRh, which, unlike other temporal cortical areas, also projected to the ba-solateral and basomedial nuclei of the amygdala. These findings define the complete sequence of connections linking primary auditory cortex with the amygdala in the rat. In addition, the findings indicate that the ventral portion of TE1, designated TE1v, has connections that distinguish it from dorsal TE1, namely, dense projections to AL and a diminished number of corticocortical projections ipsilaterally and contralaterally. Finally, the results suggest a topographic organization to the cortical terminations within the amygdala.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. M. Rodgers, A. M. Benison, A. Klein, and D. S. Barth Auditory, Somatosensory, and Multisensory Insular Cortex in the Rat Cereb Cortex, April 18, 2008; (2008) bhn054v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Knapska, K. Radwanska, T. Werka, and L. Kaczmarek Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse Physiol Rev, October 1, 2007; 87(4): 1113 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Puckett, P. K. Pandya, R. Moucha, W. Dai, and M. P. Kilgard Plasticity in the Rat Posterior Auditory Field Following Nucleus Basalis Stimulation J Neurophysiol, July 1, 2007; 98(1): 253 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Polley, H. L. Read, D. A. Storace, and M. M. Merzenich Multiparametric Auditory Receptive Field Organization Across Five Cortical Fields in the Albino Rat J Neurophysiol, May 1, 2007; 97(5): 3621 - 3638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Zhu, R. R. Stewart, J. M. McIntosh, and F. F. Weight Activation of Nicotinic Acetylcholine Receptors Increases the Frequency of Spontaneous GABAergic IPSCs in Rat Basolateral Amygdala Neurons J Neurophysiol, November 1, 2005; 94(5): 3081 - 3091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Anglada-Figueroa and G. J. Quirk Lesions of the Basal Amygdala Block Expression of Conditioned Fear But Not Extinction J. Neurosci., October 19, 2005; 25(42): 9680 - 9685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ji, N. Suga, and E. Gao Effects of Agonists and Antagonists of NMDA and ACh Receptors on Plasticity of Bat Auditory System Elicited by Fear Conditioning J Neurophysiol, August 1, 2005; 94(2): 1199 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Ma and N. Suga Long-term cortical plasticity evoked by electric stimulation and acetylcholine applied to the auditory cortex PNAS, June 28, 2005; 102(26): 9335 - 9340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Apergis-Schoute, J. Debiec, V. Doyere, J. E. LeDoux, and G. E. Schafe Auditory Fear Conditioning and Long-Term Potentiation in the Lateral Amygdala Require ERK/MAP Kinase Signaling in the Auditory Thalamus: A Role for Presynaptic Plasticity in the Fear System J. Neurosci., June 15, 2005; 25(24): 5730 - 5739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pare, G. J. Quirk, and J. E. Ledoux New Vistas on Amygdala Networks in Conditioned Fear J Neurophysiol, July 1, 2004; 92(1): 1 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Richter-Levin The Amygdala, the Hippocampus, and Emotional Modulation of Memory Neuroscientist, February 1, 2004; 10(1): 31 - 39. [Abstract] [PDF]
|
|
|
|
|
|
P. SAH, E. S. L. FABER, M. LOPEZ DE ARMENTIA, and J. POWER The Amygdaloid Complex: Anatomy and Physiology Physiol Rev, July 1, 2003; 83(3): 803 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Szinyei, O. Stork, and H.-C. Pape Contribution of NR2B Subunits to Synaptic Transmission in Amygdaloid Interneurons J. Neurosci., April 1, 2003; 23(7): 2549 - 2556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. O. Hamm, A. I. Weike, H. T. Schupp, T. Treig, A. Dressel, and C. Kessler Affective blindsight: intact fear conditioning to a visual cue in a cortically blind patient Brain, February 1, 2003; 126(2): 267 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pikkarainen and A. Pitkanen Projections from the Lateral, Basal and Accessory Basal Nuclei of the Amygdala to the Perirhinal and Postrhinal Cortices in Rat Cereb Cortex, November 1, 2001; 11(11): 1064 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.S.L. Faber, R. J. Callister, and P. Sah Morphological and Electrophysiological Properties of Principal Neurons in the Rat Lateral Amygdala In Vitro J Neurophysiol, February 1, 2001; 85(2): 714 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Szinyei, T. Heinbockel, J. Montagne, and H.-C. Pape Putative Cortical and Thalamic Inputs Elicit Convergent Excitation in a Population of GABAergic Interneurons of the Lateral Amygdala J. Neurosci., December 1, 2000; 20(23): 8909 - 8915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Linke and H. Schwegler Convergent and Complementary Projections of the Caudal Paralaminar Thalamic Nuclei to Rat Temporal and Insular Cortex Cereb Cortex, August 1, 2000; 10(8): 753 - 771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gao and N. Suga Experience-dependent plasticity in the auditory cortex and the inferior colliculus of bats: Role of the corticofugal system PNAS, July 5, 2000; 97(14): 8081 - 8086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Chowdhury and N. Suga Reorganization of the Frequency Map of the Auditory Cortex Evoked by Cortical Electrical Stimulation in the Big Brown Bat J Neurophysiol, April 1, 2000; 83(4): 1856 - 1863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Weisskopf, E. P. Bauer, and J. E. LeDoux L-Type Voltage-Gated Calcium Channels Mediate NMDA-Independent Associative Long-Term Potentiation at Thalamic Input Synapses to the Amygdala J. Neurosci., December 1, 1999; 19(23): 10512 - 10519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Amorapanth, K. Nader, and J. E. LeDoux Lesions of Periaqueductal Gray Dissociate-Conditioned Freezing From Conditioned Suppression Behavior in Rats Learn. Mem., September 1, 1999; 6(5): 491 - 499. [Abstract] [Full Text]
|
|
|
|
|
|
M. G. Weisskopf and J. E. LeDoux Distinct Populations of NMDA Receptors at Subcortical and Cortical Inputs to Principal Cells of the Lateral Amygdala J Neurophysiol, February 1, 1999; 81(2): 930 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Shi and M. Davis Pain Pathways Involved in Fear Conditioning Measured with Fear-Potentiated Startle: Lesion Studies J. Neurosci., January 1, 1999; 19(1): 420 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Stutzmann, B. S. McEwen, and J. E. LeDoux Serotonin Modulation of Sensory Inputs to the Lateral Amygdala: Dependency on Corticosterone J. Neurosci., November 15, 1998; 18(22): 9529 - 9538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Armony, G. J. Quirk, and J. E. LeDoux Differential Effects of Amygdala Lesions on Early and Late Plastic Components of Auditory Cortex Spike Trains during Fear Conditioning J. Neurosci., April 1, 1998; 18(7): 2592 - 2601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X F Li, G E Stutzmann, and J E LeDoux Convergent but temporally separated inputs to lateral amygdala neurons from the auditory thalamus and auditory cortex use different postsynaptic receptors: in vivo intracellular and extracellular recordings in fear conditioning pathways. Learn. Mem., January 1, 1996; 3(2-3): 229 - 242. [Abstract] [PDF]
|
|
|
|
|
|
G. E. Stutzmann and J. E. LeDoux GABAergic Antagonists Block the Inhibitory Effects of Serotonin in the Lateral Amygdala: A Mechanism for Modulation of Sensory Inputs Related to Fear Conditioning J. Neurosci., June 1, 1999; 19(11): RC8 - RC8. [Abstract] [Full Text] [PDF]
|
|